The only possible exception is for certain cartomizers (screw on juice carts) very thick 100% VG liquids can be too thick to flow well inside. And for some reservoir cartomizers some say anything with more PG than 80pg/20vg may be more prone to leaking. PG is thinner and lets through more TH so it can be a bit harsher, VG is thicker, smoother, makes more visible vapor but cuts TH somewhat (a lot if there is a lot of VG in the juice)
I find 70pg/30vg (or 80pg/20vg for more TH) are nice blends for the base. And 50/50 can be nice for desserty flavors.