By substantially reducing the number of cigarettes smoked per day and exposure to their numerous hazardous toxicants, e-Cigarettes may not only improve asthma symptoms and pulmonary function but may also confer an overall health advantage in smokers with asthma (Polosa et al., 2013b). Therefore, e-Cigarette use in asthmatic smokers who are unable or unwilling to quit should be exploited as a safer alternative approach to harm-reversal (i.e., specific reversal of asthma-related outcomes) and, in general, to harm-reduction (i.e., overall reduction of smoke-related diseases).