I've vaped straight PG for awhile now, I'm allergic to PG. I don't know if you mean no flavoring or nicotine, just 100% O nic, O flavor PG? You CAN do that if you want, but you can also go ahead with 100VG and a lot of people do that. I use a nautilus 2 tank, with 1.8 coil, and the only issue that I've found is that I have to replace my coils more frequently as they gunk up. Getting vapor isn't a problem though. You may want to ask for extra flavor (if you want flavor) as PG can be less flavorful... I don't find it to be, but it can happen. Certain flavors seem to work better for me-- citrus, peppermint, and coco are what I'm using ATM, fairly intense flavors so even with pure VG, it's fine. I haven't tried unflavored, no nicotine VG, but I guess I could. Certain vape shops will only sell up to a certain percentage of nicotine as often pure VG users are sub-ohming and are thus getting more nicotine, possibly? I don't find, the way I smoke, using the tank and wattage I do (14 watt) to have any issues regarding being over-nicotine-ized...