The biggest advantage is that you get a fresh atty whenever you pop in a new carto. I never really like the atty anyway. If you use an atty, you must drip to get the best of it. There are two types of cartos, you just need to try out the filler cartos and the fillerless which is the CE2.
For both of em there are pros and cons. The CE2 will leak at the top but not by much, the filler carto is quite robust when it comes to leaking but doesn't produce good vapor and flavor as compared to the CE2s. However, CE2s can be used for many more times compared to the filler cartos as the wick doesn't degrade and the atty can be cleaned with dry burns. Filler cartos will degrade after some time and when the time comes, you must throw them away.
The next step is to fiddle with the resistance of the carto, you will learn that certain resistance works best with certain juice to provide good TH. Again for that, you just have to try what works best for you.
These are my CE2s and filler cartos with syringe tube mod. They make filling and cleaning easier, no syringe required just dripper bottles. I don't use filler cartos anymore but this pic will give you some idea of what to do...i'll be more than happy to answer any questions...cheers and happy vaping
