Actually, it's not all that big or uncomfortable
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The joint of my thumb is right over the button. For a right-hand vape, you can switch the USB connector to the other side, and your forefinger can bend to hit the button if you want to vape with the device facing the other way. The first joint of my fingers wrap around for vaping, just showing you the size here.
The bottom of the unit is flat, so it will stand on it's own. For tanks you prefer to sit on their sides, you can obviously lay it down
As is, it's a fairly unisex device, but as you can see, I manned it up a bit. I can definitely see possibilities to girly/pretty it up as well. A trip to a craft store and there are all kinds of stickers and themes you can work in on the large flat surfaces.