Refrigeration/freezing won't affect PG/VG or nicotine in fact it will prolong the life if stored properly. The problem with storing pre-mixed eliquid(vendor or DIY)in the frig is the flavorings...
Quoted from an emil sent by Linda at The Perfumer's Apprentice about storing food flavorings. A long read but lots of good info.
"Concentrated flavors do not spoil, or go rancid, like fruit juices can.
But under certain conditions they can change.
Basically, what my flavor manufacturer tells me is that the flavors have a shelflife of at least six-months to one-year, when they are not continuously opened. It is not necessary to store them in the refrigerator, but I dont think that this would hurt them. But sometimes refrigeration can cause re-crystallization of flavors that have a lot of the crystals like ethyl maltol in them.
Every concentrated flavor is a mixture of raw materials, and every flavor blend can act differently. For example flavors that have a vanilla characteristic are going to have slightly different storage capabilities than fruit flavors. Heres the reason.
Vanilla and caramel flavors are mostly made of large molecules like vanillin, ethyl vanillin , etc.
These molecules are not very volatile, and tend not to escape the bottle when you open it. They will be fairly stable. Fruit flavors, on the other hand, are made of much smaller molecules in general. Whenever you open a bottle, its the lightest and smallest molecules that escape and reach your nose quickly. Over time when you open a bottle over and over again more and more proportion of these lighter molecules leave the bottle and eventually the character of the flavor will be changed. This doesnt mean the flavors spoiled, its just different. So this is one piece of advice, if you are going to store a flavor for a long period of time, transfer the flavor to smaller bottles that will you will not have to open over and over again.
also, when a flavor is warm, like if its a hot day, when you open the bottle even more of the volatile molecules will escape, much more will escape than if the flavor was cool. This is true for all liquids, when liquids are heated the molecules are much more easily converted to their gaseous state. So in general it is a good idea to keep the flavor cool though I dont think refrigeration is always necessary.
Also, in general, it is best not to store these flavors long-term in plastic.
The plastic that we ship our larger sizes in ( 4 ounces and above), is HDPE plastic, which is very resistant to interaction with the flavors.
but even with HDPE plastic, I really wouldnt recommend storing them for longer than a month or so.. Its much better to store things long-term in glass.
also, it is not a good idea at all to store the flavors with the plastic eyedropper caps on the bottles. The rubber thats used with the eyedroppers is extremely soft and interacts."