I came up with a method to easily refill these w/o a needle. I just bored out the refill hole so that it is bigger, then put the dropper bottle right into it a you would do with the needle and fill it. Duh!
Depending which version of the E2 carto's you get, there's a little silicone o ring. That would probably prevent any leakage. I do this anyways even though I fill with a syringe, because the flexible plastic tip that comes for refilling doesn't even fit in the holes. I just poke a 21 gauge syringe in there, then pull it out, then fill with the plastic tip.
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