The heaviness I get from high VG is in the lungs, not horrible but it's just harder to move; I only get this doing intense aerobics, but have chosen to normally vape no higher than about 50% VG, unless it's testing something that I have made for another person.
A headached from vaping hard -- maybe slightly too much nic? I would drop from my normal 24 down to 12 for chain vaping. (Now I'm at 10 mg/ml, use it all around)
Say you have an eliquid which is 80% PG, had about 12% total flavoring by volume (1.2 ml of flavoring in 10 ml of final eliquid). If you now switch to, say, 80% VG, you might find that the flavoring needs to be bumped up a bit, to say 15% total.
The % are a hassle at times. I generally just go for the dominant %, and that's what I label the bottle with. For instance, if I am using a 100% PG nic base, I'll count all the ml of nic base towards my PG % (don't sweat the little bit that's actually the nic). Likewise if my flavorings are all nominally PG, then those ml all count towards the PG %, I don't sweat the fraction of the flavorings that is the actual flavoring content.
The "outliers" are when I am making something special, for people who are sensitive to either PG or VG, those bottles get labeled as "0PG" or "0VG". In those cases I have made sure that my flavorings have no PG (or VG). I personally don't like to call something 100%PG or 100%VG because those are incorrect in anything I make -- there's always some % of nic, flavorings, and often alcohol in organic flavorings.