In principle, top-coil tanks like a Halo Trition or a Genny shouldn't leak with pressure changes if kept upgright.
Yes they will. Just because they are top coil doesn't mean they still don't rely on a pressure differential to stay sealed. If they didn't then every time I took a puff off my Halo while lying on my back I would end up with a mouth full of juice. It's going to draw juice through the wick just like you were sucking on it and all of that excess juice is going to flow out the chimney either out the mouthpiece or through the bottom to the 808 connector.
Someone suggested using an empty air tight pill bottle or some sort of container big enough to put your tanks in, it helped some or worked pretty good.
That may work depending on where you're flying from and to.
For instance, if you're flying from Miami to Los Angeles then you're at sea level at both locations. Air pressure will be equal when you open the lid.
However, if you're flying from Miami into Aspen then you're looking at an almost 8,000 foot change in altitude. The second you open that lid the tank is going to spew.
It will work fine provided the altitude of your point of departure and destination are relatively close to each other. Also, keep in mind that the higher in altitude you go the faster the air pressure drops per 100 feet. Sea level to 1000 feet won't cause any leaking at all. 14,000 to 14,265 feet can cause leaking (Speaking from experience).