As i write this i feel a pain in my right chest, it varies from the left to right side. I've been vaping since Nov. 6 (the elections, which is when my twists came in... R.I.P. those poor guys, never had a chance with my party life style) anyways, my chest hurts on and off when i chain vape, my throat used to get sore too but i am going with softer juices and dont have a problem with that anymore. (currently smoking a 650mah vv with a vivi nova 1.8ohm at about 3.7v)