Yes, I try not to stress my batteries. I've got 3 matched pairs dedicated to my Vapor Flask, so it' no trouble for me to pull them out a bit early.
I get a good two days vaping from 4.2-3.7v, and then swap them out.
My setups are normally around 0.6ohms, but I only get through 4ml of juice a day on average.
It's one of the reasons I stick with 12mg juice, so I don't constantly have the drip tip in my mouth like a pacifier