Well, the batteries are usually to discharge down to ~2.6V. I would not recommend going that far down, as what's known as copper shunts may start to form, causing irregular discharge points inside the cell, creating spot heating and increased cell heating greatly increasing chances of thermal runaway. I've overdischarged every once in a blue moon with various projects. It's risky, especially with steel canned batteries.
A thought: Vaping with mech mods is that power goes down significantly with the voltage since the load is of a (nearly) constant impedance. It may stop giving you good results around 3V or so. Assuming you're running a 1.3 ohm coil you'd be only getting ~7W, which is almost half at what you'd be getting at 4V (~12W). .8 ohms 20W@4V, 11.25W@3V, etc etc. It may have just fallen far below your preference and is still well above the danger point of overdischarge. Though, you should check. Seriously.
Most of the 18650 chargers I've seen do not push the battery in charging. A low voltage cutoff charger is great for such an unmonitered system. Though, it's not the normal operating charger that is scary...
Thermal runaway is a concern of all batteries, but the conditions are rather outside the normal operating conditions by a large portion. The lowest point at which thermal runaway typically starts in a lithium is around 100degC. Internal heating is an issue, and one way to do that is by drawing too much current... The other, by external heating, which (should) be fairly negligible unless you've been leaving your battery/mod on your car dashboard in a Oklahoma/southern state region. Combining those two is rather dangerous. IE Dashboard scenario combined with .2 ohm coil abuse afterword. The third, is the one I find scary since I know how often solid state devices can fail. Charger failure by the regulator fet shorting. The charger will act fine, but is actually putting 5V on the batteries. Yikes! If a cheap charger is used, the regulator will just say it's charging and continue on with it's job monitoring the voltage. Eventually the batteries will vent (with flame) from CO2 production.