When you build in series, you double the voltage, but you are still running off the max amp rating of one battery. If you build parallel, the voltage stays the same, but you double the max ampacity. In a series build, 21A is not safe unless you have 30A batteries. But it's fine in a parallel build with 20A batteries.
And that's assuming the batteries are working together perfectly.
In the real world, even with 'married-for-life' pairs of batteries one is likely to be working harder than the other in a given situation. If the difference is 20%, you'd better have a 20% cushion with your expectations.
The pulse rating is similar to an auto maker's specification regarding braking/stopping capability. They might claim, "60mph to 0 in 150 feet, (or whatever)." Would you trust them on that when you're barreling down on a crosswalk full of pedestrians?
A very wise old logger told me many years ago, "Rule number one is: don't cut faster than you can think."
That advice has kept me out of trouble in a number disciplines.