IMR cells are far from impervious to failure. They can go up in flames. I read of that happening to someone with an all mechanical
mod here at ECF. The person had her AW IMR 14500 powered mod in a bag and discovered it all burnt and exploded in there.
Most of the ICR cells have a built-in PTC such as the Panasonic NCR18650A. Even so, Panasonic tells you in their literature a protection PCB is required for that cell. I wouldn't bet my life on it, but I'm pretty sure the the AW IMR cells do not have a built-in PTC.
I know of no supply issues running a PTN04050C booster with an IMR 14500 and was not claiming there are any. An IMR 14500 has a drain limit of almost 5A which is enough for 15W of output, more than the PTN04050C booster is capable of putting out.
I was only pointing out there is zero short circuit protection when using a boost regulator with an IMR cell. Chances are probably good that an IMR cell will not go up in flames if shorted, but I would not want to find out the hard way. Why take the risk when a 50 cent part can address any concerns.