This is one of the things that makes vaping really fun for me. I just recently put a twisted 26g coil in one of my tanks, put in this strawberry milk I've been vaping, and noticed right away that the flavor was wrong. It was just the milk while the strawberry was totally muted. Pulled that coil and put in a 26g contact micro coil wrapped on a magic blue screwdriver and it was right back to juicy strawberry flavor country.
Coil structure, resistance, power/temp, Air to vapor ratio, location and direction of the airflow, chimney/chamber dimensions, juice being used, and probably 100 other things I've never even thought of.