I just rinse mine in water, but I use fruit flavors almost exclusively. If you have a really strong, sticky flavor, you might have to do a little more to get rid of it.
I usually stick to a flavour when i start using it, i have two evods and use diff flavours in em, when i do swap flavours i dont always clean the cartomizer out tho, as long as there isnt much liquid in the cartomizer i cant feel much diffrence in the flavour.
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