To the OP...I use both Cisco's LR306's and the regular 306's. The only big difference that I've noticed is how much warmer the vaper is off the LR's. This really doesn't bother me (not a dislike or a like). I'm neutral in that respect. The flavor and vaper are about the same to me. I vape on a 3.7v Icon and also eGo batteries but only use the LR's on my Icon. Joye also makes the 306's in both types. They don't last as long as Cisco's but produce almost the same flavor/vaper. Not quite but almost.