I can get an irritated eye from vapor but mainly from rubbing my eye when I had traces of
eliquid on my fingers. Nicotine is quite a skin irritant, especially in 100% PG juice which lets through the most flavor, the most nicotine TH and the most nicotine irritation.
Clean your ecigs occasionally with w barely damp cloth or a clorox wipe, and after you fill, if you get any liquid on your fingers, wash your hands. I often just wipe them on a tissue (or my jeans) and that is not enough - if I touch my lashes or rub my eye, I will get dry and irritated there.
If you are using 100% PG juice, try 80PG/20VG with stuffing cartos or 70PG/20VG with tanks or reservoir cartos or atomizer.
If the vapor is blowing in your eyes, rearrange where you sit or how you vape. I tend to not blow the vapor very far and the way the air flows at my desk at work it does blow back in my face. And when I french the vapor ( let it billow out of my mouth to inhale with my nose to get the aroma) some may go up past my nose to my eyes.