Contribution of nicotine to acute endothelial dysfunction in long-term smokers..

[ladyraj]

Ex-smokers who choose to vape nicotine must overcome the myriad of allegations of harm attributed to nicotine usage...the latest is endothelial dysfunction. The study I link to actually compares a single cigarette and the nicotine nasal spray.

CONCLUSIONS: These results demonstrate that nicotine alone causes acute endothelial dysfunction, although to a lesser extent than smoking a cigarette of the same nicotine yield. However, the precise mechanisms by which nicotine leads to this altered vascular reactivity remain unclear. (C) 2002 by the American College of Cardiology.

So in harm reduction parlance...nicotine all by itself causes this "dysfunction" despite the fact the exact "mechanism" is unknown...thus nicotine is harmful even in "accepted" products. Therefore, there is no safer level.

Fight this and we may have a chance!

Link: http://en.scientificcommons.org/33286362

One can do a search of endothelial dysfunction and will get thousands of hits. One can narrow the search by using "and" with nicotine. I have a working theory that this form of ED underlies cholesteral and inflammation. What say you?

Or this can be used to demonstrate that the Nasal Spray are harmful in comparison to the e-cig. just a thought.

 

[a2dcovert]

So in harm reduction parlance...nicotine all by itself causes this "dysfunction" despite the fact the exact "mechanism" is unknown...thus nicotine is harmful even in "accepted" products. Therefore, there is no safer level.

I have never considered nicotine to be safe. I went into this with my eyes wide open and knew the nicotine risks. The bottom line for me was the risks are lower with the e-cig compared to the cigarette even on this one point. My health issues included significant lung problems which have completely dissappeared. On that point alone it is worth the switch. Nicotine is not good for the body, but when you are addicted to it, getting it through a safer method is OK in my book.

K

 

[Tugger]

Here's the Wiki on it:

http://en.wikipedia.org/wiki/Endothelial_dysfunction

I guess studies on long term SNUS use that show no increase in morbidity should help allay some concerns about this.

 

[Magestorm]

Not all science is out to get us. The study was to see if it was nicotine alone, or other contents of tobacco smoke.

From what I can see, it was a proper test, and showed vascular dilation is slightly impaired when nicotine is used. The source seems not to matter. If anyone is really concerned about that, then you just dial down the mg/ml of nick in your e-juice, and reach 0 nic.

But, this addresses the cardiovascular system, which we understood would have SOME effects. But, where the electronic cigarette shines compared to the regular cigarette is the reduction or elimination of the carcinogens, carbon monoxide, and other components in tobacco smoke, as well as eliminating second hand smoke and this "third hand smoke".

 

[Kate51]

Ladyraj, we could save them an awful lot of work, start the timing : X Now!
We'll just keep track of how many puffs we vape until we go to meet our maker, that will be the last entry in my diary. Ok. Who should we send our notes to after we're gone.

http://en.scientificcommons.org/33286362

will probably be gone by then too.
Some contest. PLEASE DON'T stick any of that new cold remedy up your nose, you know the one!

 

[Computer Extreme]

eat yer fresh tomatoes or grow 'em:

BBB : Vol. 63 (1999) , No. 1 pp.78-82

 

[Xerxes]

There is also an article "Basic cardiovascular research and its implications for the medicinal use of nicotine" from the Journal of American College of Cardiology that says nicotine isn't that bad. It might even promote blood vessel growth and protect heart muscle. But then again it lead to insulin resistance and then there's that study that started this thread. Of course, I cant post the URL because I haven't made 15 or more posts.

 

[River]

You can manage your risk for endothelial dysfunction with exercise and a good diet, it's more difficult to manage risk (but of course diet and exercise help) with Parkinson's disease except for using nicotine.

This is just an ignorant laypersons opinion but I think I would rather chance the alleged endothelial dysfunction that comes with nicotine use than to give up the conclusive evidence that emerged after 40 years of study that nicotine users have a 50% reduced risk of Parkinson's.

From the link: "Studies conducted over the last 40 years show that the incidence of Parkinson's disease is about 50 percent less in smokers than in the general population."

http://www.sciencedaily.com/releases/2007/10/071024093555.htm


In the end you rolls th' dice and you takes your chance-eses...

 

[Slither]

Caffiene causes vascular changes and insulin resistance as well..all things in moderation I suppose. I never thought nicotine was "safe". There are some studies though that show cognitive increases with it, similar to nootropics. I switched to vaping to get rid of the smoke part, but don't know that I necessarily want to quit nicotine and the "act" of smoking..it is relaxing to me and gives me a moment of pause to think things through sometimes.

 

[CES]

The receptors that bind nicotine naturally respond to acetylcholine and are present in many parts of the body, not only in the brain. The activation of one type of nicotinic receptor is responsible for muscle contraction and we wouldn't be able to move without this activation. Nicotinic receptors in the brain are associated with learning and memory. Other nicotinic receptor types are expressed in the skin cells and cells that line the vascular system- though their purpose isn't yet well understood. The use of nicotine can affect many systems of the body, including the brain pathways associated with addiction (I can give links to references if anyone wants them). It's not clear that every effect of nicotine use is harmful, however it is clear that many of the 4000 other compounds in cigarette smoke are harmful. I'll take my chances with vaping and the hope of harm reduction....

 

[Quitter man]

well according to the new Eissenberg study (you can search about it here in this forum) it suggest that ecig deliver ZERO nicotine!!!!! go figure ..I don't really know what to believe any more when it come to ecig and nicotine !!

 

[Vocalek]

well according to the new Eissenberg study (you can search about it here in this forum) it suggest that ecig deliver ZERO nicotine!!!!! go figure ..I don't really know what to believe any more when it come to ecig and nicotine !!

All the Eissenberg study proves is that 10 puffs from an NJOY NPRO or Crown 7 doesn't deliver much nicotine to neophyte users. You can't generalize from this that nobody gets any nicotine from any electronic cigarette under any circumstances.

 

[Vocalek]

You can manage your risk for endothelial dysfunction with exercise and a good diet, it's more difficult to manage risk (but of course diet and exercise help) with Parkinson's disease except for using nicotine.

This is just an ignorant laypersons opinion but I think I would rather chance the alleged endothelial dysfunction that comes with nicotine use than to give up the conclusive evidence that emerged after 40 years of study that nicotine users have a 50% reduced risk of Parkinson's.

From the link: "Studies conducted over the last 40 years show that the incidence of Parkinson's disease is about 50 percent less in smokers than in the general population."

Parkinson's Disease: Nicotine Reduces Levodopa-induced Dyskinesias


In the end you rolls th' dice and you takes your chance-eses...

Amen. Watching my mother busily unlearning everything she ever knew is impetus enough for me. Her diagnosis is "Lewy Body Dementia" which includes not just memory and reasoning problems, but also delusions and hallucinations. Lewy Bodies are the things that cause Parkinson's, and her disease includes the balance problems and stiffening that are slowly taking away her mobility. She falls down a lot. She says it feels as if her feet are glued to the ground (and for those in the know,she has been checked for NPE --another possible cause of this type of immobility -- and does not have that).

Just hand me the nicotine. There is no other preventative measure.

 

[Grammie]

Amen. Watching my mother busily unlearning everything she ever knew is impetus enough for me. Her diagnosis is "Lewy Body Dementia" which includes not just memory and reasoning problems, but also delusions and hallucinations. Lewy Bodies are the things that cause Parkinson's, and her disease includes the balance problems and stiffening that are slowly taking away her mobility. She falls down a lot. She says it feels as if her feet are glued to the ground (and for those in the know,she has been checked for NPE --another possible cause of this type of immobility -- and does not have that).

Just hand me the nicotine. There is no other preventative measure.

Vocalek, what is NPE? My husband can't pick his feet up and falls alot. Neurosurgeon operated on his neck...but didn't fix his mobility problem. I've been trying to find other things that might cause his problem, but no luck so far.

Sorry if this is totally off topic. Desperate at this point.