FDA Could the FDA really regulate E-Liquid??

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Before we all freak out, can I ask you what your source is? And precisely what you heard? I'd prefer a verbatim quotation with whatever context you can supply. We just got through having a discussion on this very thread about something that was reported second-hand (see post #51).

I'm not disbelieving you, I just would like the closest thing to facts that we can get, as opposed to characterizations and/or summations.

For example, what does 69% mean? Concentrations are also relevant, as we all know from the anti-vaping junk science floating around (i.e. "e-cigarettes contain ____").

Also see this thread for some context on the significance of concentrations: http://www.e-cigarette-forum.com/fo...s-may-contain-diacetyl-there-really-many.html

Again ... I am not attacking you, your source of information, or disbelieving you or your source of information.

I just want the most precise facts that are presently available.

Has anyone given any thought to the future of eliquid and regulation, with regard to safety - after the report from Dr Farsalinos comes out? From what I gather, he's not just going to release his results to vapers - it's going to be a peer-reviewed published report. And it's going to say that 69% of liquid tested contains diacetyl or similar.

So when all the news headlines shout that ecigs give you 'popcorn lung', how can the FDA ignore that? Can they then regulate or ban that liquid under some other regulations other than the TCA? Will that give them the impetus to ban every other delivery method but sealed cartridges? And how many people will believe ecigs are healthier and switch to vaping after hearing that?
 
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squee

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Before we all freak out, can I ask you what your source is? And precisely what you heard? I'd prefer a verbatim quotation with whatever context you can supply. We just got through having a discussion on this very thread about something that was reported second-hand (see post #51).

The source is the good Doc himself - go to approx 1:25:05 for the relevant info

https://soundcloud.com/vp-live/smoke-free-radio-episode-3

For example, what does 69% mean? Concentrations are also relevant, as we all know from the anti-vaping junk science floating around (i.e. "e-cigarettes contain ____").

Sorry, my fault in not being clear. 69% is the percentage of liquids in which Dr F found diacetyl, not the % of diacetyl found :) So 109 out of 159 liquids contained it, in some as yet unspecified concentration, world-wide.
 

Bob Chill

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Has anyone given any thought to the future of eliquid and regulation, with regard to safety - after the report from Dr Farsalinos comes out? From what I gather, he's not just going to release his results to vapers - it's going to be a peer-reviewed published report. And it's going to say that 69% of liquid tested contains diacetyl or similar.

So when all the news headlines shout that ecigs give you 'popcorn lung', how can the FDA ignore that? Can they then regulate or ban that liquid under some other regulations other than the TCA? Will that give them the impetus to ban every other delivery method but sealed cartridges? And how many people will believe ecigs are healthier and switch to vaping after hearing that?

Luckily diacetyl's source isn't one of the base ingredients. If it was a byproduct of vaporizing pg/vg/nic then it's a pretty big deal. Since I got into this almost a year ago, it's been pretty clear that the flavorings are the biggest wildcard in regards to chemical safety of the hobby. Diacetyl is quite common in things we eat. And we all inhale vaporized diacetyl in the kitchen. Just not in quantities high enough to warrant any concern.

It would be really easy to control the existence of or quantity of diacetyl in juice as an industry standard. The industry is currently moving in that direction by itself. IMO- this particular issue will prove to not be an issue shortly down the road.
 
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The source is the good Doc himself - go to approx 1:25:05 for the relevant info

https://soundcloud.com/vp-live/smoke-free-radio-episode-3

Sorry, my fault in not being clear. 69% is the percentage of liquids in which Dr F found diacetyl, not the % of diacetyl found :) So 109 out of 159 liquids contained it, in some as yet unspecified concentration, world-wide.

Thanks, you saved me from having to listen to the other show in which Dr. F. called in. Unfortunately there isn't much more info. than you reported because I thnk Dimitri wanted to talk about how the industry responded, and how vapers should respond. So we really don't know whether it's merely the presence of any diacetyl or an amount that would exceed the tolerances. We can be sure, however, that this is going to be in every news outlet in America :( ... "Dr.s study: E-cigarettes kill with more than cancer"

There is also another chemical which I believe I'm spelling correctly (I did some googling, because Dr. F. talks fast). Dimitri's volume wasn't up very high, so I had to slow it down and speed it up all the time. But here is what I have after a couple of listenings:

***

[1:24:32]

Dr. F:. Yeah, I think we are ready to report the preliminary results. We have received all results and will have done all testing. We tested 159 flavors in total, testing involved analysis for the presence of diecityl and acetyl propylene. Ah ... I think ... ah ... most vapers and most vendors know the issue of diacetyl, ah ... it was first mentioned in this industry since 2010 but unfortuantely there were a lot of companies who substituted diacetyl with acetyl propylene without knowing that ah ... some ... ah .. some animal studies have shown that acetyl propylene which is a similar substance to diacetyl, causes also similar lung problems ah .. in experimental animals ... at the same ... almost the same levels.

Dimitri: The same levels that we find in diacetyl we find with the substitute ingredient that was being used, um, especially after the big thread that happened back in 2010 on the ECF, correct?

Dr. F.: Yes, and in reality acetyl propylene is another substance that should not be used in e-cigarettes. Ahh ... now, we tested 159 samples from all over the world, a large number of vendors, both from several countries in Europe, and from the US, ahh, the results I can say were pretty disappointing --

Dimitri: [interrupting] yeah ... before we get into the results, we have to mention that the vendors that were used, were, ah, all the way from the Moms and Pops shops, all the way to some large companies - the large scale of e-liquid manufacturers that were tested as well -

Dr. F.: Yes, exactly, without a lot of large, big companies, big in size, and small-sized companies but ... so we-we tried to ... eh ... have a representative sample of whole industry, whole world-wide industry. So ah, [pause] the results I think were pretty disappointing. and ah, were worse than I was expecting. Ah, we found approximately 69% of the samples being positive for diacetyl alone. Some of them also contained acetyl propylene, there were also some others which did not contain diacetyl but contained acetyl propylene, only. Ah, moreover, we had several samples from companies who publicly declared that their liquids are diacetyl-free, and they came up positive.

Dimitri: So for example, you go on a web site for an e-liquid and this manufacturer has posted that 'our e-liquids are diacetyl-free' - however those samples tested for diacetyl and of course the other substance as well.

Dr. F.: Yes, and they came up postiive. Ah, now, ah ... I'm not accusing the vendors ... ah, I think there was a big mistake in the strategy. And this mistake started from 2010. Ah, the mistake was that when the issue of diacetyl came up in the e-cigarette business, every vendor just asked this flavoring supplier whether the liquid, their flavorings, had diacetyl or not. And they just accepted an oral response or a phone response that 'no, our flavorings are diacetyl-free'. They didn't ... ever ask for proof that they are diaceytl-free, which means the result of testing

Dimitri: [indecipherable]

Dr. F.: Oh, no ... chemicials analysis, make sure that the liquid is diacetyl-free, and I think that was the problem, it's not that the vendors knew that the liquids were -

Dimitri: right

Dr. F.: containing diacetyl, and just try to hide it, it's basically that the vendors didn't even know ...

Dimitri: And obviously the vendors didn't do the testing themselves, as well--

Dr. F.: Exactly -

Dimitri: --on the [indecipherable] they basically went on the word of the flavoring company, they didn't test it, the vendor themselves didn't test it [indecipherable]--

Dr. F.: Although in my opinion, I think that it's the job of the flavoring supplier to do the test. Ah ... the problem is that the ... ah ... the e-cigarette vendors are the ones who are marketing the products so at the end it's their responsibility to the consumers --

Dimitri: ultimately

[I gave up here because Dimitri was not consistently at the same volume and I had to keep showing it down and speeding it up because Dr. F. talks really fast and Dimitri fades in and out. There's nothing more about the results ... ended transcribing at 1:28:56 approx.]

Dr. F. says that we should not "create a panic," and the levels of these two chemicals post much less of a risk than smoking, but also that they are avoidable risks. He continues ...

"So although the risk is small, just because it's an avoidable risk, there is no reason to impose that small risk to the customers. Therefore what I can suggest to vendors is that they can either ask the flavoring suppliers to provide proof of the absence of diacetyl and acetyl propylene in the flavoring which means testing results - not [just any] kind of response through a phone conversation or any conversation. That's not enough. If they cannot do that, and they cannot change the supplier with someone else who can do it, or wants to do it, then it's up to them, and it's their responsibilty to do the testing. But testing I think is absolutly necessary because otherwise no one can be sure that the liquid will be diacetyl-free. And it is a substance that we already know it is toxic when inhaled, so there is no reason to impose that risk, even if the risk is lower than smoking. Still, it's a risk that can be avoided. And we should avoid it."

[later, also from Dr. F.:]

[Vapers] should ask the vendors to publically post the results of thesting and this is a good marketing benefit for vendors. [paraphrased]


1:27:35
 

aubergine

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Oh CRAP. :(

I remember the 2010 thread well, and many subsequent discussions in here. Despite the lower-risk-than-cigarettes, this issue (unlike so many) is real. I wish I could pretend that it isn't.
Some will; many in here have been dismissive, others (like myself) have sought mindful vendors and made efforts to avoid juice that contains diacetyl or acetyl propylene. The only vendor that I purchase from has taken great pains both to educate customers about the problem and to ensure that his product is free of toxins (he tests) and I've been angry that others haven't done the same, for health reasons and for just the reason that has now emerged here.

(see Ingredients
and What's in YOUR E-Juice? ) It can be done.

This is an issue that should have been a central concern (edit - a more fervently pursued concern; I'm very aware of the persons in ECF who wanted more pressure on vendors in this) in our efforts to make this a properly consumer-regulated product. I understand that the casualties attributed to diacetyl involved the inhalation of quantities of the stuff, but as unknown long-term dangers go, that one is the only one with any scientific weight. I chain-vape, don't want the stuff in my lungs or in anyone's unless they're fully aware of the risk. Minimizing it is not gonna fly with the public or the FDA.

It's a real gotcha for the other side.

Bah.

(Bob Chill, I agree that this is actually an easy problem to fix, but the timing sucks - the buzz won't be around requiring vendors to test, but the fact that they don't; previously vague claims that vapor contains "unknown dangerous chemicals of all sorts" will be given credence.)

(Good work as usual Roger, thanks. That one was a hard one to 'like'. I try not to shoot the messenger.)
 
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Jman8

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Dr. F.: Yes, and in reality acetyl propylene is another substance that should not be used in e-cigarettes. Ahh ... now, we tested 159 samples from all over the world, a large number of vendors, both from several countries in Europe, and from the US, ahh, the results I can say were pretty disappointing

*2nd bold emphasis mine

This is pretty disappointing news, but not unexpected from my perspective. Still fits in with paradigm of relatively harmless. But have a doctor (presumably on our side) say the results were disappointing for 70% of samples tested and I'm thinking ANTZ is going to have a field day with this.

Just made the case for US federal regulation a little more solid.

Especially considering that Dr. F. is giving benefit of doubt (which I agree with) in saying the vendors didn't know. So, if industry doesn't know what precisely it is putting out, then how are consumers/vapers supposed to pretend that 'we have this covered, no need for assistance from the feds?'

The great news is this diacetyl problem can be addressed/corrected, and in some cases already is.
The good news is this still makes for a realistically relatively harmless product, but...
The bad news is this makes for a question of 'how harmful,' and a point, which if the 'anti-freeze' meme is of any historical guide, will only be around for the next 5 years in the media.
 

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*2nd bold emphasis mine

This is pretty disappointing news, but not unexpected from my perspective. Still fits in with paradigm of relatively harmless. But have a doctor (presumably on our side) say the results were disappointing for 70% of samples tested and I'm thinking ANTZ is going to have a field day with this.

Just made the case for US federal regulation a little more solid.

Especially considering that Dr. F. is giving benefit of doubt (which I agree with) in saying the vendors didn't know. So, if industry doesn't know what precisely it is putting out, then how are consumers/vapers supposed to pretend that 'we have this covered, no need for assistance from the feds?'

The great news is this diacetyl problem can be addressed/corrected, and in some cases already is.
The good news is this still makes for a realistically relatively harmless product, but...
The bad news is this makes for a question of 'how harmful,' and a point, which if the 'anti-freeze' meme is of any historical guide, will only be around for the next 5 years in the media.

Yep. It would be hard to make up worse news.
 

Katya

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of diecityl and acetyl propylene.

The chemicals in question are: diacetyl (and acetyl propionyl and acetoin, which seem to be replacing diacetyl in custard flavors, but are also somewhat suspect). Nothing new. We've been discussing possible risks of inhaling diacetyl for ever.

He also mentions diketones

Another one is cinnamaldehyde--discussed here ad nauseum. If you want links, I'll be happy to oblige.

Farsalinos on Flavors at SFATA Conference in Chicago - ECF InfoZone
 
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aubergine

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Nothing new to us, of course. But it's a credible study, and that's a lot of samples, and the FDA et alia will be most pleased. As far as I know they never publicly tested for that after finding those - two cartos was it? - in 2010.

Is the thing.

Deeply hope I'm wrong that this will be a big deal out there.
 
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Katya

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The great news is this diacetyl problem can be addressed/corrected, and in some cases already is.
The good news is this still makes for a realistically relatively harmless product, but...
The bad news is this makes for a question of 'how harmful,' and a point, which if the 'anti-freeze' meme is of any historical guide, will only be around for the next 5 years in the media.

Honestly, I don't see it a very bad news. I don't want harmful chemicals in my juice. I stopped vaping buttery/custard and cinnamon flavors a long time ago. I know that responsible vendors and flavoring manufacturers have been trying to remedy this problem for quite a while. Kurt wrote about dangers of diacetyl (acetyl propionyl, acetoin) and cinnamaldehyde at length and often (long before Dr. Farsalinos appeared on the scene).

We all know that the flavorings/colorings/additives/sweeteners are and will be a problem.

My main issue is with nicotine itself, frankly.
 

Katya

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Nothing new to us, of course. But it's a credible study, and that's a lot of samples, and the FDA et alia will be most pleased. As far as I know they never publicly tested for that after finding those - two cartos was it? - in 2010.

Is the thing.

Deeply hope I'm wrong that this will be a big deal out there.

Farsalinos on Flavors at SFATA Conference in Chicago - ECF InfoZone

The scientist concludes with the point that “what is avoidable should be avoided.” No particular chemical is essential to the vaping experience. If a particular flavoring turns out to entail unacceptable risk, another can be sought. This is in stark contrast to the risky chemicals users sustain when smoking combustible cigarettes. The harmful chemicals delivered to the user in smoking are produced by the combustion itself, and are unavoidable.
 

Kent C

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Honestly, I don't see it a very bad news. I don't want harmful chemicals in my juice. I stopped vaping buttery/custard and cinnamon flavors a long time ago. I know that responsible vendors and flavoring manufacturers have been trying to remedy this problem for quite a while. Kurt wrote about dangers of diacetyl (acetyl propionyl, acetoin) and cinnamaldehyde at length and often (long before Dr. Farsalinos appeared on the scene).

We all know that the flavorings/colorings/additives/sweeteners are and will be a problem.

My main issue is with nicotine itself, frankly.

Not the news itself, but how it will be used against us. Think Prue, who's likely already grabbed the notes from here. No one's going to wade through Roger's "explanation" or if they do they'll just dismiss it.
 

Katya

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Not the news itself, but how it will be used against us. Think Prue, who's likely already grabbed the notes from here. No one's going to wade through Roger's "explanation" or if they do they'll just dismiss it.

Yes. But seriously, at this point, it doesn't really matter what they say--they are completely discredited, at least in my eyes. They are liars and they will lie, no matter what.

On the other hand, researches like Farsalinos are honest--they present their results without whitewashing and spin.

Just look at this list:

E-cigarette research, studies and papers
 

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Kent C

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Yes. But seriously, at this point, it doesn't really matter what they say--they are completely discredited, at least in my eyes. They are liars and they will lie, no matter what.

On the other hand, researches like Farsalinos are honest--they present their results without whitewashing and spin.

Just look at this list:

E-cigarette research, studies and papers

You're right of course. But the media will still run with it. We should use it as a 'plus'. Dr. F gains credibility - actually something to bring up on how we're 'self-regulating'.
 

Katya

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Besides, diacetyl (and thousands of much more dangerous chemicals) are also present in tobacco.

Determination of toxic carbonyl compounds in cigarette smoke - Fujioka - 2006 - Environmental Toxicology - Wiley Online Library

The general decreasing order of the carbonyl compounds yielded was
acetaldehyde (1110–2101 g/cigarette1) > diacetyl (301–433 g/cigarette1), acrolein (238–468 g/cigarette
1) > formaldehyde (87.0–243 g/cigarette1), propanal (87.0–176 g/cigarette1) > malonaldehyde
(18.9–36.0 g/cigarette1), methylglyoxal (13.4–59.6 g/cigarette1) > glyoxal (1.93–6.98 g/cigarette1).

Diacetyl has been widely used in flavor compositions,
primarily in imitation butter, caramel, coffee, and cream
soda, as well as in tobacco (Arctander, 1969). It is also
present in natural products such as essential oils and fruits.
Diacetyl is included in the USDA-GRAS (United States
Department of Agriculture-Generally Recognized As Safe)
list
(http://vm.cfsan.fda.gov/dms/eafus.html)
 
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Jman8

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You're right of course. But the media will still run with it. We should use it as a 'plus'. Dr. F gains credibility - actually something to bring up on how we're 'self-regulating'.

If we were dealing with objective media, the Dr. F. thing wouldn't be a big deal. To me, the news isn't a big deal cause product is still relatively harmless. But as you noted, ANTZ/mainstream media is going to treat diacetyl (that appear in eCigs ONLY) as akin to the plague and run that story for all its worth.

Plus, the comments by Dr. F. that he is/was disappointed. That looks like bias, even while astute/objective observers would easily be able to note that he wasn't actually biased when it came to the science. Can't say that for ANTZ scientists, even with regards to traditional cigarettes.

I honestly expected news such as this back in 2012, that would be discovered by an objective scientist which shows some legitimate level of harm in eCigs, and then some degree of panic, even among vapers. All trying to downplay the relative harmlessness of the product. Get enough people to believe the negative hype and it is similar to what smokes have had to contend with in last 20 to 50 years.
 
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