for the most part I would just buy another clearo when I was using those. other times I would drain as much as I could hit the unit till things go to slightly off flavor and then add my new flavor in vape it for a few min and flavor changed that easy. I would try to stay with flavors that went well together for a change over like peach and mango or kiwi and strawberry. you can certainly change out the wick and coil keep it in a small ziplock bag labeled with what flavor for future use.