About the only "negative" to nicotine is "vasoconstricor" (means is makes your veings clamp down smaller) however nicotine alone isn't any harder on the old bod than a cup of java! It's the OTHER chemicals in ciggy's that really smacked the body DOWN.
From a SMOKE standpoint, picture standing in a forrest fire (essentially this is what we did to our bodies when we smoked), the aveoli got clogged UP HARDCORE. The tobacco burning (ASH) actually clogs up the air sacks, aveoli, in our lungs. So what happens is they "bleed" then scar UP. Needless to say when you scar up whole sacks, well you can't breath for squat. You body has to work harder to get 02 to your brain (and other parts of your body).
Vapeing is much like standing in a HOT shower! H2O molecules are MUCH larger than the ash in smoke. And vape doesn't clog up and scar your "air sacks". So from a purly LOGICAL standpoint, well it makes SENSE that vapeing is much easier on a body than smoking.
If you look at old scars on your body they ARE faded. This is essenetially what is happening in lungs of all vapors. We've done some damage that will NEVER go away. But the longer we stay away from SMOKE (and the ash), the better our lungs can actuate, or heal up and start working like they are SUPPOSED too. WHen lungs work they way they are SUPPOSED to work, well they get 02 in and the heart doesnt' have to work as hard oxy'ing the old bod up. Ergo, the heartrate goes DOWN!