...
We can take in large doses of nicotine which is a toxin.
Logic says that we can take in much more nicotine than with smoking although Ruyan research suggests less per puff (I dispute their figures, see -
http://www.e-cigarette-forum.com/forum/general-e-smoking-discussion/6525-draws-puffs-per-ml.html and
http://www.e-cigarette-forum.com/fo...7216-can-someone-help-me-math.html#post110153). We can also vape and get zero nicotine so I'd say it's a matter of education and making informed, responsible choices with available nicotine levels.
We don't know for sure how much of the nicotine we use transfers from liquid to our bloodstreams. Anecdotal evidence suggests that it can be well above our tolerance levels.
We don't know what prolonged inhaling of glycerine or PEG400 does to our bodies.
http://www.e-cigarette-forum.com/fo...ble-glycerine-glycerol-safety-discussion.html
http://www.e-cigarette-forum.com/fo...g-new-ingredient-instead-pg-vg.html#post91677
We don't know what prolonged inhaling of other additives and flavourings in eliquid does to our bodies.
"... I do think artificial flavors are a potential concern, and the biggest unknown..." - Leaford
GRAS (generally regarded as safe) chemicals may be safe to ingest but assumptions about safety to inhale are not valid - diacetyl, a food flavouring causes lung disease.
http://www.e-cigarette-forum.com/fo...oking/2666-inhaling-flavouring-chemicals.html
I guess assessing this risk requires information on ingredients in the eliquid we use, knowledge about our exposure levels (chronic/mild?) and information on how particular chemicals react and accumulate.
Dose-response relationship - Wikipedia, the free encyclopedia
We don't know how the cocktail of chemicals we inhale interacts.
We don't know if there are chemicals given off by the atomiser coil wick as it degrades.
http://www.e-cigarette-forum.com/fo...anufacturers-suppliers-whats-my-atomizer.html
http://www.e-cigarette-forum.com/fo...12335-analysis-black-gunk-atomizer-coils.html
We don't know what type of plastics are used for storage or cartridges and if they leech chemicals.
http://www.e-cigarette-forum.com/forum/health-safety-e-smoking/2519-bpa-concern-e-smoking.html
"Most plastics do have to pass conformity tests." - 0ogier
We don't know what chemicals are given off by cartridge fillers when they are heated or burned.
http://www.e-cigarette-forum.com/forum/health-safety-e-smoking/992-danger-filter.html
We don't know about what sort of paint is used on devices, it could contain lead.
"Lead in paint - RoHS certification. Yes admittedly only for those tested but that is the same as enything."
- 0ogier
We don't know if there is a safety risk with having a battery/power supply so close to our faces.
"Battery / power supply close to head - I suppose you can look at mobile phones and hearing aids." - 0ogier
Faulty switches, chargers or batteries could cause fires.
"Charger safety risk / faults - CE certification" - 0ogier
We don't know if standards of hygiene or purity of product are maintained effectively at manufacturing facilities because there is no regulation of production.
"Hygene standards . Again by certification. ( in the case of my supplierSGS GMP Codex ,food hygene) ." - 0ogier
I might be wrong here but I've only noticed Chinese manufacturers getting certification for eliquid. European and US eliquid makers don't bother to voluntarily have tests done and don't have any regulation to make them comply with good standards for hygiene or ingredients?
...
"... there is no regulation of production..."
To clarify, ... as far as I know there are no regulations covering production of eliquid anywhere, just voluntary good practice checks and balances. Hardware is probably covered by guidelines for electrical and other appliances but not specific standards (for example relating to composition of coil wicks, etc)...