There are many factors at play here, for example:
- The PG and VG in e-liquid bind the nicotine to a certain extent, that is to say they 'lock it in'. In addition, it is at a very low strength when mixed ready for vaping - around 1% to 4% of the strength of the original pure nicotine liquid.
- This means there is a world of difference between spilling pure nicotine, or nicotine mixed with water, onto the hands. You have time to wash it off, because the low strength combined with the binding effect of of PG together with the fact it cannot penetrate the skin rapidly, means there is a timelag before it can penetrate the skin and take effect.
- There is a huge difference in tolerance to nicotine between individuals. We know it is at least a factor of ten - that is to say, an individual with high tolerance can tolerate ten times the amount of nicotine an individual with low tolerance can. So it depends where you are on the scale. If you are a 6mg or 12mg vaper then you should take considerably more precautions than a 36mg vaper - you have less tolerance to nicotine and therefore the effects of over-consumption are likely to be more pronounced.
Persons who are not sure what the effect of e-liquid spillage might be for them, should take the necessary sensible precautions. If you've spilled high-strength liquid on yourself and did not experience any unpleasant effects (increase in heart rate / jittery feeling / headache / tingling extremities) then *perhaps* you may have a higher tolerance.