Yep. It's all just a method of applying voltage to a coil. In the case of a 100W mod the atomizer is anything that can deal with a sub ohm coil. Above the 1 ohm point, 30 watts is plenty. The range on the 100W iStick is 5W to 100W, so you can vape virtually any tank that fits, with most any coil as long as it's a 510 connector or one that adapts EGO threads to 510.