Propylene glycol is used:
As a moisturizer in medicines, cosmetics, food, toothpaste, mouth wash, and
tobacco products
As a medical and sexual lubricant (A.K.A. "personal lubricant")
As an emulsification agent in angostura and orange bitters
As a solvent for food colors and flavorings
As a humectant food additive, labeled as E number E1520
As a carrier in fragrance oils
As a less-toxic antifreeze
As a solvent used in mixing photographic chemicals, such as film developers
In smoke machines to make artificial smoke for use in firefighters' training and theatrical productions
In electronic cigarettes to make the produced vapor better resemble cigarette smoke
In hand sanitizers, antibacterial lotions, and saline solutions
In cryonics
As a working fluid in hydraulic presses
As a coolant in liquid cooling systems
To regulate humidity in a cigar humidor
As the killing and preserving agent in pitfall traps, usually used to capture ground beetles
To treat livestock ketosis
As the main ingredient in deodorant sticks.
Propylene glycol has similar properties as ethylene glycol (MEG). The industrial norm is to replace ethylene glycol by propylene glycol.
[edit] Safety
Cases of propylene glycol poisoning are related to either inappropriate intravenous use or accidental ingestion by children.[4] The oral toxicity of propylene glycol is very low. In one study, rats were provided with feed containing as much as 5% PG over a period of 104 weeks and they showed no apparent ill effects.[5] Because of its low chronic oral toxicity, propylene glycol is generally recognized as safe (GRAS) for use as a direct food additive.
Serious toxicity will occur only at extremely high intakes over a relatively short period of time that result in plasma concentrations of over 4 g/L.[6] Such levels of ingestion would not be possible when consuming reasonable amounts of a food product or dietary
supplements containing at most 1 g/kg propylene glycol.
The U.S. Food and Drug Administration (FDA) has determined propylene glycol to be "generally recognized as safe" for use in food, cosmetics, and medicines. Like ethylene glycol, propylene glycol affects the body's chemistry by increasing the amount of acid. Propylene glycol is metabolized into pyruvic acid, which is a normal metabolite in the breakdown of glucose, while ethylene glycol is metabolized into oxalic acid, which is toxic.
However, propylene glycol is not approved for use in cat food. The U.S. Food and Drug Administration has determined that propylene glycol in or on cat food has not been shown by adequate scientific data to be safe for use. Use of propylene glycol in or on cat food causes the feed to be adulterated and in violation of the Federal Food, Drug, and Cosmetic Act. 21CFR589.1001
Prolonged contact with propylene glycol is essentially non-irritating to the skin. Undiluted propylene glycol is minimally irritating to the eye, and can produce slight transient conjunctivitis (the eye recovers after the exposure is removed). Exposure to mists may cause eye irritation, as well as upper respiratory tract irritation.[7] Inhalation of the propylene glycol vapors appears to present no significant hazard in ordinary applications. However, limited human experience indicates that inhalation of propylene glycol mists could be irritating to some individuals. Therefore inhalation exposure to mists of these materials should be avoided. Some research has suggested that propylene glycol not be used in applications where inhalation exposure or human eye contact with the spray mists of these materials is likely, such as fogs for theatrical productions or antifreeze solutions for emergency eye wash stations.[8]
Propylene glycol does not cause sensitization and it shows no evidence of being a carcinogen or of being genotoxic.[9][10]
Recent Clinical Journal of Medicine article states two cases of adult men experiencing psychosis from use of propylene glycol used in phenytoin injection USP. Both patients had to be switched to Cerebyx (Fosphenytoin Sodium) in order to avoid propylene glycol co-solvent.
Research has suggested that individuals who cannot tolerate propylene glycol probably experience a special form of irritation, but that they only rarely develop allergic contact dermatitis. Other investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater than 2% in patients with eczema.[11]
Patients with vulvodynia and interstitial cystitis may be especially sensitive to propylene glycol. Women struggling with yeast infections may also notice that some OTC creams can cause intense burning.[12]Post menopausal women who require the use of an estrogen cream may notice that brand name creams made with propylene glycol often create extreme, uncomfortable burning along the vulva and perianal area. In these cases, patients can request that a local compounding pharmacy make a "propylene glycol free" cream which is much more tolerable.[citation needed]
Propylene glycol - Wikipedia, the free encyclopedia
