Many odors, fragrances, oils, etc, used to set my migraines off. I was on preventive meds for decades, terrible side effects, yet better than 3-5 debilitating migraines a week. Although I had a few migraines a year the virtually chronic, continuous migraines didn't start up till my late 30's. That being said, one of my most favorite foods, all my life has been onions, almost any kind. When the frequent migraines abruptly started one major trigger was onion oils. So the reaction was "in my head" yet not in the sense of the labels people use frivolously.
I'm still sensitive to many odors but most usually they set off my migraine vertigo. Now that I don't get the painful migraines two months ago I got really brave and prepped up 20 lbs of onions for precooking a bit and freezing. Throughout I had to stop and sit down because of migraine vertigo and was unable to drive for over a day. After that I lost the ability to smell and taste several of my favorite things and still can't smell or taste them.
That's neurological and not my imagination. Saying all of this because your dear wife may have something real going on.
That being said, I can only vape a very few flavors without getting dizzy, nauseated, stuffy, etc. The only flavors I can really tolerate are butterscotch based with a few hints of vanilla, cinnamon, and a few others thrown in lightly for variation.
I'm also sensitive to flavorants, food coloring, and oils by getting skin rashes, even from airborn, and/or lips, tongue, throat swelling, and lung congestion. (Yeah, most of the time I need to be in a bubble.)
You might be highly surprised by how good non flavored nic juice does taste and feel.
That being said, lots of air movement around the house helps a lot. Ceiling fans all over. Just don't ever let the air stop moving. When I did a vaping video I had to turn off 8 fans in the downstairs part of house to the vapor wouldn't immediately blow off. Yet I can't stand much air blowing directly on me so movement facilitators are strategically placed.
We use sonic air cleaners near where we sit for TV and sitting work and near beds, and air filtration around the house. Our central AC/furnace has three layers of filters.
Keep the air moving is best bet.
I might add that although I'm extremely sensitive to many, many things, and have been since birth, most animal hair and dander doesn't bother me much; only a little itching and rashes at worst. Pollen, dirt, dust, barnyard, etc., are little problem. In fact I've lived with 6-12 Large and GIANT country housedogs, for over 30 years but we only have five now. They let us live in their kennel. I'm frequently around new world monkeys with no issues but I once had anaphylaxis from Rhesus Moneky dander so I avoid enclosed spaces with old world monkeys. (AnaKit is my constant companion.)
A small air filter won't do a lot if you are vaping close to the Mrs. Get some air movement going and try some of the suggestions others have given.
I'm so on your side here and feel for ya.
The Feisty