I wouldn't let it run down too much. Once a cartomizer dries out, it may be a lost cause to try to make it taste good again. I'd suggest refilling as soon as the vapor drops off a little bit, and then...
The refill method, which has wowed the cartomizer community is Dogbody's carto cap refill (or "condom") technique, e.g., as demonstrated by Doctor Vapor:
BTW, there are many other (less expensive) suppliers of the Kr8 model and cartomizers for it, often sold under different brand names (as does Electronic Cigarettes Inc.). Just in the U.S.: Vapor4Life (Vapor King), NHaler (KR808D-1), AltSmoke (KR808D), CigEasy (Easy), Cigtechs (KR808D), GoodProphets (VapoRite), LeCig (D1), Liberty Flights US (KR808D-1), LiteCigUSA (KR808D-1), Mist-Stix (Mist-Stix), PureSmoker (Ace), The House of Vapor (KR808D-1), VaporKings (KR808D-1), and VaporNine (Nebula).