That's about as subjective a question, as how do you smoke analogs? Everyone get's different mileage out of their PV, and their own style.
One thing that has been commonly discussed, is that drawing with less pressure than an analog, and slower gives better results. But those considerations are more due to equipment, and not getting a mouthful of juice!
I personally don't immediately exhale about one out of four vapes. For me, it seems to get more nicotine into my system, so holding that one out of four in, satisfies my NIC urge quicker than just inhale/exhale.