Inositol? Can help former smokers

[geeker]

Saw on NBC Nightly news that a supplement called inositol can help prevent dysplastic lung cells from turning malignant in current and former smokers.

It's available at health food stores.

 

[geeker]

A little more info...

Inositol is sometimes called Vitamin B-8.
Caffeine depletes the body's supply of inositol.
It has been used to treat depression and OCD.

I have access to any medical journal ever published, so I will definitely be checking into this.

 

[keyzygirl]

Post whatever you find please.

 

[ImYourSalt]

i used to use inositol to turn 9 oz of something, into 12 oz of something...

i didn't know it had other positive benefits!

 

[geeker]

Myo inositol and lung cancer
A phase I study of myo-inositol for lung cancer chemoprevention.
Cancer Epidemiol Biomarkers Prev. 2006 Aug. Lam S, McWilliams A, LeRiche J, MacAulay C, Wattenberg L, Szabo E.
Department of Respiratory Medicine, British Columbia Cancer Agency, British Columbia, Canada.
A phase I, open-label, multiple dose, dose-escalation clinical study was conducted to assess the safety, tolerability, maximum tolerated dose, and potential chemopreventive effect of myo-inositol in smokers with bronchial dysplasia. Smokers between 40 and 74 years of age with more than 30 pack-years of smoking history and one or more sites of bronchial dysplasia were enrolled. A dose escalation study ranging from 12 to 30 g/d of myo-inositol for a month was first conducted in 16 subjects to determine the maximum tolerated dose. Ten new subjects were then enrolled to take the maximum tolerated dose for 3 months. The potential chemopreventive effect of myo-inositol was estimated by repeat autofluorescence bronchoscopy and biopsy. The maximum tolerated dose was found to be 18 grams per day. Side effects, when present, were mild and mainly gastrointestinal in nature. A significant increase in the rate of regression of preexisting dysplastic lesions was observed versus placebo (91% versus 48%). A statistically significant reduction in systolic and diastolic blood pressures by an average of 10 mm Hg was observed after taking 18 g/d of myo-inositol for a month or more. Myo-Inositol in a daily dose of 18 g orally for 3 months is safe and well tolerated.

 

[geeker]

Shame on you, Salty!

 

[ImYourSalt]

WHAT!? I said "used to"...

On the bottles I bought, it said for cellular detoxification. if you are looking to buy some, don't get it from GNC. They charge an arm and a leg. you can get it online for about a quarter of the price.

 

[geeker]

OK, you're forgiven.

 

[Katya]

Gene found that may predict lung cancer in smokers‎

 

[geeker]

bump-it's important!

 

[keyzygirl]

Very interesting.

 

[Trish342]

I went to the vitamin shop and got some this morning. Here is the news report on it.......

NBC Nightly News with Brian Williams: News and videos from the evening broadcast NBC Nightly News with Brian Williams: News and videos from the evening broadcast- msnbc.com

It wont hurt you so I think it is worth a try.

 

[TropicalBob]

This is a most interesting development. Studies tell us that the incidence of lung cancer actually increases during the five years after a smoker quits. That happened to my receptionist years ago. She quit cigarettes and died of lung cancer a few years later. Inositol shows promise in preventing tragedies like hers.

I am adding it to my own daily supplement supply. With no side effects of consequence to worry about, why not?

 

[Adik Ted]

I will look into it myself. Thanks for posting this geeker.

 

[geeker]

I, too, went to the health food store today. Got one bottle of inositol and one bottle of inositol/choline.

I checked for interactions with my prescription and OTC meds. I'm going to start with 1 cap inositol/choline and 2 more of the inositol-only, per diem.

 

[Janetda]

The stuff I read was talking about 8 grams a day, that's like what 14 pills? 8-o

 

[Katya]

I, too, went to the health food store today. Got one bottle of inositol and one bottle of inositol/choline.

I checked for interactions with my prescription and OTC meds. I'm going to start with 1 cap inositol/choline and 2 more of the inositol-only, per diem.

This is the dosage per the Canadian study cited above.

Myo-Inositol in a daily dose of 18 g orally for 3 months is safe and well tolerated.

Are you taking an equivalent?

And, by the way, have you seen the thread about COPD and Vitamin D3? Very interesting. I can find the link, if you're interested.

There you go:

COPD, The E-Cig and Me

 

[miss MiA]

I'm going to start with 1 cap inositol/choline and 2 more of the inositol-only, per diem.

May I ask how you arrived at the particular regime above? (Maybe it's in the story but my connection isn't cooperating with it atm!)

And the amounts of the active ingredient/s in the caps you'll be taking (however they list it, grams, mg. IU, etc.)?

The tests lasted 3 months but was there an indication as to whether the inositol should be taken indefinitely, or..?

TIA!!

Oh, in a very brief check it appeared 'Myo-inositol' is the same as inositol; pls. correct if mistaken!

 

[geeker]

The stuff I read was talking about 8 grams a day, that's like what 14 pills? 8-o

That would be 16x500 mg capsules.
That's for treatment of active OCD and depression.

AFAIK there's no recommended prophylactic dose.
Have not finished all of the research I plan on doing.

However, if the research said to take 16 caps a day, I'd probably do it.

 

[bestthingever]

Can anyone recommend a good online source for this & other supplements ? One that is reputable ?