Concerning how much nic is absorbed, here's the recent Etter writeup:
http://www.stop-tabac.ch/fra/images...p_tabac/e-cig cotinine final erj 20110111.pdf
Experienced vapers using 5 cartridges/refills a day, call it 2.5 - 3 ml/day, of an average 18 mg/ml. Median cotinine level was 322ng/ml. As a comparison, in a prior study,
Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers., for smokers (> 10 cig/day) the mean cotinine level was around 283 mg/nl in saliva.
Net, the experienced vapers had cotinine levels pretty similar to active smokers, indicating roughly the same total amount of nicotine being metabolized.
Note that the cotinine levels for smokers were for nominal, just >= 10 cigs/day.
Now, the person who is vaping up near 5 ml of 36 mg/ml/day might be expected to be roughly 4X the level of the vapers from the Etter letter, about twice the ml and twice the mg/ml. Comparing it to the earlier study, that would be around 4X the mean value for the smokers. That would mean it is probably up around the equivalent of 40 - 80 cigs/day worth of nicotine being metabolized (this is just a ballpark), more likely in the higher zone, roughly 3 - 4 packs a day equivalent.
The amount (ml) consumed by the vapers in the Etter letter may well be higher than 2.5 - 3 ml/day, this is just a rough guess, I wish the respondents stated their consumption in ml, but such is life. If they were really vaping more like 5 - 6 ml/day, then that would mean the person vaping 5ml of 36 mg/ml per day would only be metabolizing about the same as, perhaps, 2 PAD.
Net, we do definitely metabolize the nicotine, at least experienced vapers do. For me, I definitely notice it as I'm dropping my nic level, a day or so of increase in consumption that then drops back down to normal. On the other hand, we are also not metabolizing anywhere near 100% of the nicotine, as if we were the vapers would have really high cotinine levels (and we'd all be bouncing off the walls).
The other interesting thing, from the earlier study (the non vaping one), is that it measured non-smokers and passive smokers too. They had non-measurable saliva and plasma cotinine levels, and both groups had measurable, but really tiny, urine cotinine levels.
Hopefully this is of interest
