original post by drozd:
I think that you also have to take into consideration that there are different grades of PG..industrial vs comercial vs pharmaseutical
here's a link I find better than the one you had provided
Ethylene Glycol and Propylene Glycol Toxicity: What is Propylene Glycol | ATSDR - Environmental Medicine & Environmental Health Education - CSEM from the CDC's Agency for toxic substances and disease registry
basically in any case where there was any toxic response to PG it was administered either topically (over burns) or via IV in concentrations way higher than we could possibly get via
vaping...
particularly convincing to me are a combination of these statements on the page I linked
"FDA considers an average daily dietary intake of 23 mg/kg of body weight to be safe for persons 2-65 years of age"
that's dietary so the absorption would likely be higher and that's 23mg PER kg of body weight so an average say 75kg (165 lb) person would have to ingest 1725mg of pg to hit that safe daily dietary intake
couple that with this:
"Half-Life
The elimination half-life of propylene glycol is about 4 hours."
Propylene glycol is metabolized in the liver by alcohol dehydrogenase to
•lactic acid, and then
•pyruvic acid
Both of these metabolites are normal constituents of the citric acid cycle and are further metabolized to
•carbon dioxide and
•water
About 45% of an absorbed propylene glycol dose is excreted by the kidneys unchanged or as the glucuronide conjugate.
so you'd have to be
vaping the equivalent of ingested 1725mg of PG in the span of 4 hours to even break that safe threshold before it's turned into carbon dioxide and water and eliminated from the body...that's totally unlikely even for the heaviest of vapers
*as a side note I only
vape PG as it's far more known and documented, and used in breathing treatments... than VG which is sold as a skin protectant and not labeled to be used internally...in fact there's a warning to NOT use it over deep puncture wounds and the like