As others said, get the iStick 30W instead.
The iStick 20W doesn't have a buck converter. That means that no matter what you set the wattage at it cannot drop the voltage below the battery charge. So, for example, if you were using the 1.6ohm coil in the Nautilus and your battery was freshly charged it would fire at 11W even if you had it set lower. The iStick 30W has the buck converter and can reduce voltage which not only means it can vape at lower wattage settings correctly, but the battery charge will last longer if you do.
That said, your Nautilus will work best in the 12-20 watt range. I typically use mine at 15W for sweet or darker juices and up to 19W with clear juices with little to no added sweeteners. It works best with 60/40 or 50/50 PG/VG ratio juice but you can use a 40PG/60VG juice in it as well. I wouldn't recommend anything more than 60% VG though or it begins to be too thick for the wicking material. Higher than 60% PG tends to be too thin and may cause gurgling and flooding of the coil.