Stepping down to natural tobaccos or "organic" or whatever can be helpful. I did, and my docs are pretty sure that's ONE reason I wasn't dead five years ago and whatever (you should see a doctor's face when you tell them the "truth" that you are a 3 ppd smoker). One big difference I noticed was no more staining of my hands and fingers, well nowhere near what it was.
I don't know that "organic" cigarettes means a whole lot (I mean, it's kind of self-policing as it were) but it may do SOMETHING depending on your brand. I did find using organic tobacco that I really couldn't stomach smoking ANYTHING else, so there have to be some differences and whatnot.
It might be a reasonable step in the right direction. But even just tobacco is filled with alkaloids, (and tar, if you burn it, which ALSO has been found to be an MAOI-B in at least one NIH study) the alkaloids are frequently MAIO-A and MAIO-B (and probably traces of other) substances, which are found to decrease depression and anxiety much like the medications themselves can.
So, a certain amount of "detox misery" can be expected. Usually after a while your brain will return to homeostasis. If you are having a particularly awful time with detox, you could look into WTA (whole tobacco alkaloid) juices, they are expensive, don't work for everyone but they certainly helped me as I was detoxing from tar. Aroma is probably the "gold standard' for their WTA juices, priced accordingly and Umbavape or Ohm's vapors (I believe they are somehow related to each other, the two companies) offer versions for far less expense. I actually like both, but I'm not sure it's a fair comparison, as I really was in the throes of detox when I used Aroma's. I will say, I didn't need much and weaning from them is far easier than from tobacco, because you aren't going to absorb as much, probably, but they definitely played a role in my success and I still keep some around for stressful situations. E.g. my mom plans to visit in August, so I will be loading up a tank, pretty full, is my guess. Etc.
Best of luck,
Anna