Probably not. Since the cart filter is not a filter per se,but saturated with the liquid itself, not designed to filter smoke the way say, an analog, is. The only thing that I would be concerned about are higher heating temperatures as this would 'boil off' or vaporize the juice faster increasing the concentration per draw.
Now if you are disciplined enough only to use your PV 1. when a nicotine urge hits and 2. Only enough to satisfy the craving, I don't think you would have to worry about the heat factor either. That being said I haven't reached that point.