Nicotine absorption -- what's in your cup?

What's in your cup?

  • Neutral drinks (pH 6.6 to 7.5) & am satisfied with 24mg or below.

  • Neutral drinks (pH 6.6 to 7.5) & need stronger than 24mg liquid.

  • Neutral drinks (pH 6.6 to 7.5) & need other sources of nicotine in addition to vaping.

  • Mildly acidic drinks (pH 5.0 to 6.5) & am satisfied with 24mg or below.

  • Mildly acidic drinks (pH 5.0 to 6.5) & need stronger than 24mg liquid.

  • Mildly acidic drinks (pH 5.0 to 6.5) & need other sources of nicotine in addition to vaping.

  • Moderately acidic drinks (pH 3.6 to 5.0) & am satisfied with 24mg or below.

  • Moderately acidic drinks (pH 3.6 to 5.0) & need stronger than 24mg liquid.

  • Moderately acidic drinks (pH 3.6 to 5.0) & need other sources of nicotine in addition to vaping.

  • Very acidic drinks (pH 2.0 to 3.5) & am satisfied with 24mg or below.

  • Very acidic drinks (pH 2.0 to 3.5) & need higher than 24mg liquid.

  • Very acidic drinks (pH 2.0 to 3.5) & use other sources of nicotine in addition to vaping.

  • I usually don't have anything to drink while vaping.


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isande

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Poll Instructions:

Your answer should be based on what you drink most often while you are vaping or within half an hour before vaping.

If your drink of choice is not listed below, please post and I will try to find out what pH it is. If it's a commercial drink, be sure to include the brand! I will also add it to the list below.

Neutral drinks (pH 6.6 to 7.5):

  • Water (tap, bottled, filtered.. any plain water)
  • Milk
  • Home-brewed tea without lemon

Mildly acidic drinks (pH 5.1 to 6.5):

  • Coffee (with or without cream, milk, sugar, creamer)
  • Tea with lemon
Moderately acidic drinks (pH 3.6 to 5.0):

  • Sierra Mist (and Diet Sierra Mist)
  • Mountain Dew Code Red (Diet Mountain Dew Code Red)
  • Pepsi One
  • Fresca
  • Diet 7Up
  • All orange soda and diet orange soda
  • All root beer and diet root beer
  • All creme soda and diet creme soda
  • v8 and V8 Splash
  • Nestea bottled tea
  • Snapple bottled tea
  • Orange juice
  • Pineapple juice
  • Regular grape juice (not white grape juice)
  • Apple juice
  • Pear juice
  • All Juicy Juice blends
Very acidic drinks (pH 2.0 to 3.5):

  • All soda except those listed above.
  • Lemonade and limeade
  • Cranberry juice and cranberry juice cocktail
  • White grape juice
  • Grapefruit juice
  • Gatorade
  • Powerade
  • SoBe bottled drinks
  • Lipton bottled tea
  • Sunny Delight, Capri Sun, Hi-C and similar drinks
  • Tang

Explanation:

I have a little hypothesis I'd like to test.

Some people seem to absorb more nicotine from the e-cig than others. This is well-established on the forums, where some former 3 or 4 pack a day smokers can use 18mg or 24mg liquid without problems, while others who smoked fewer cigarettes struggle with 36 or 48mg liquid.

It's also believed (though not by everyone) that most of the nicotine in vapor is absorbed through the mouth and throat.

It is an established fact that tinkering with the pH of oral tobacco (like Swedish snus) changes -- drastically! -- the amount of nicotine that is absorbed through the oral mucosa. In snus, a change from 8.0 to 8.5 pH amounts to a difference between about 50% of the nicotine being "active" (usable through the oral mucosa) to about 80% of the nicotine being active.

I propose that not only is much of the nicotine from vapor absorbed through the mouth and throat, but that the pH of an individual user's saliva can greatly affect how much nicotine is absorbed. Ideally, I'd buy a big vial of pH strips and mail out 3 or 4 to everyone interested in participating, but I don't have the money to spare (probably $50 or so for postage and the strips). Instead, I'm making a poll to ask about what you typically drink while you're using your e-cig.

It's not as scientific as I'd like, but I'd like to see if there's a trend...

Background:
Personally, when I was using the e-cig alone, I could literally breathe through the thing (without ever taking a breath between drags) all day long without stopping except to use the bathroom or take a shower. I was using 48mg juice, dripping, and burned out 901 atomizers in a couple of days... I had to keep five separate chargers running to keep enough batteries going.

Then I switched to Swedish snus as my primary source of nicotine and for a while I didn't bother with the e-cig. When I needed a "boost" of nicotine, I used nasal snuff. Unfortunately, I was forced to stop using nasal snuff for a few months because the medication I was on (100mg prednisone/day) suppressed my immune system and using nasal snuff caused a severe sinus infection.

Unfortunately, that meant to maintain my sanity (I have a HEFTY nicotine tolerance), I had to go back to smoking about half a pack a day (from my original 2 to 3 packs a day).

Then I gave the e-cig another try because my brother gave me an M401 as a Christmas gift. Best gift ever (if you're reading this, kc0cmp, I love the mug and enjoyed the wine and candy too! :D). The M401 solved all of the problems I personally had with using an e-cig, but more importantly, I discovered something interesting. If I had a snus portion in my mouth when I used it, even 24mg liquid was *actually working*... in fact, I only need to take 6 or 8 good long drags before I want to set it down for a while.

Meanwhile, my brother transitioned easily from smoking 3 or 4 packs a day to the e-cig, using 24mg juice, without problems. But what was the difference between he and I?

Partially, I think the habit was more of an issue for him than me. I didn't have that much of an attachment to the hand-to-mouth or rituals of smoking, but I do have a very high nicotine tolerance and dependence. Partially, I think the "other stuff" (harmaline, etc.) in whole tobacco is something I am more dependent on than he is. Partially, I think that he was more motivated to quit smoking than I ever was. For me, the e-cig and other reduced harm products are primarily a way to cut down on spending. Other benefits, like the huge health benefits of not smoking traditional cigarettes, improved sense of smell and taste, improved athletic endurance (not applicable to me at all, unfortunately), not smelling like an ashtray and (my favorite!) not having to clean up spilled ashes are just bonuses. So I went into this, in August 2009, hoping to spend less money by replacing as many cigarettes as reasonable with the e-cig.

But I don't think that fully explains why my brother could switch to vaping with 24mg liquid even though I was incapable of going a full day without a cigarette on 48mg liquid. Not only that, he reported getting a "nicotine buzz" if he used 36mg... and he wasn't using a mod or "hot burning" e-cig (like the 510) at the time. He started out with a 901 and switched to a KR808D-1 a month or so later. I bought a KR808D-1 myself and it didn't help. 48mg liquid was STILL not enough to fully cover my nicotine dependence.

Not only that, but getting a mouthful of 48mg juice didn't affect me either. I didn't bother to spit it out (after the first time, when I kind of freaked out).

So what was different between my brother and I? And why did it change when I used snus?

SALIVA pH!!!

My brother drinks filtered tap water (pH about 7, give or take) most of the time. I never drink water. I haven't had more than a tiny sip of plain water in 26 years. I drink copious amounts of diet soda with a pH of about 2.5 to 3. (Please, let's save any off-topic discussion of any health effects this practice *might* have for an off-topic section of ECF.)

In any case, I drink diet soda all day long without ever really stopping. The medications I take cause me to have a dry mouth and I consume two or three two liters of diet soda each day. There's no doubt this greatly acidifies my saliva, thus preventing nicotine from being absorbed through the mouth and throat. Snus changes this because it is high pH (about 8.5 for the brands I use).

--K
 

isande

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Aug 14, 2009
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Beer usually has a pH in the "moderately acidic" range, but microbrews and premium beers sometimes fall into the "mildly acidic" range. Typical pH for beer is between 3.7 and 4.1.

Alcohol greatly increases nicotine tolerance and desire to smoke, however. I can't recall exactly how this works; I remember something about alcohol displacing the nicotine either in the brain or bloodstream but don't recall the exact mechanism. This is why people tend to chain smoke while drinking. Several prescription drugs do the same thing -- mostly sedatives and opioid painkillers.

--K
 

pianoguy

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Very interesting poll!

I drink more coffee than anything else during the day. I typically also have 2 glasses of milk each day, and have started drinking a couple glasses of water in order to counteract deydration from PG. I started with 24mg juice and have cut down to 8-12mg strength over the past 6 weeks or so with no problem (I've been analog-free for almost 4 months). When I first got my e-cig, I immediately cut down from a pack a day to 4-5 cigs per day, and on the 4th day I put down the analogs. I had some mild cravings for the first 2 weeks or so, but nothing intolerable.
 

TWISTED VICTOR

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Hi isande. I've come across many of your posts while scouring old smokeless threads and wondered if you were still snusin'. Good to know you're still at it. I believe you're right about the pH affecting nic absorption. I've read a few studies that address this specifically, both for smokes and snus. Higher pH keeps more nic in free-base form for easy absorption in the buccal mucosa. What I haven't seen are any studies on environmental variables. Your poll may give some insight. If the saliva or eliquid pH was in that 8.5 range (smokes are generally 6.0-7.8, but absorption is ment to be through the lungs) that snus is, absorption would surely be better, but high pH drinks may not have any effect.

As far as why some folks get all they need from PV's and some continue to turn inside out, regardless of vaping mass quantities of high nic liquids, this thread got started http://www.e-cigarette-forum.com/forum/nicotine/44958-so-we-getting-we-not-nicotine.html and we've learned alot. For some of us, purified nicotine isn't enough. Some of us need the maoi effects of tobacco alkaloids to stay...er...humanly. Harmaline is part, but not all. Why??? Donno. Too many years of abuse, hereditary predisposition to depression or anxiety, injury that keeps the body from releasing dopamine as it should? I do know that, for me, speed of nic delivery is important, but it's proved to have little bearing on my psyche. That's why smokeless works for a lot of us that PV's alone never will. Here's a blog from DVap you might find interesting: http://www.e-cigarette-forum.com/fo...g-i-think-i-know-about-vaping-vs-analogs.html. Good luck on the poll. Scientific or not, sometimes consensus is all we have to go on :).
 

telsie

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Hmm. I'm not sure how to answer this poll. I am a big coffee drinker, so I am often drinking coffee when I'm vaping. But I also drink water all day long. That's pretty much all I drink: coffee and water.

I mostly vape 11mg, but sometimes I'll top off with 18mg when I just feel like I need it. I'm one of those people that still feels like something is missing (even after 5 months at this), but since dropping from my initial level of mostly 18-24mg to what I vape now, I haven't noticed any change in that "something missing" feeling. So for me anyway, it's got little if anything to do with the nicotine level itself and so probably little if anything to do with the ph of my mouth. But I like your hypothesis and I could just be an anomaly ;)
 

kurtomiser

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Hmm. I'm not sure how to answer this poll. I am a big coffee drinker, so I am often drinking coffee when I'm vaping. But I also drink water all day long. That's pretty much all I drink: coffee and water.

I mostly vape 11mg, but sometimes I'll top off with 18mg when I just feel like I need it. I'm one of those people that still feels like something is missing (even after 5 months at this), but since dropping from my initial level of mostly 18-24mg to what I vape now, I haven't noticed any change in that "something missing" feeling. So for me anyway, it's got little if anything to do with the nicotine level itself and so probably little if anything to do with the ph of my mouth. But I like your hypothesis and I could just be an anomaly ;)


Hi Telsie,

Do you feel a lack of satisfaction or is something missing from the experience of vaping?
PS I like your avitar;)
 

telsie

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Hi Telsie,

Do you feel a lack of satisfaction or is something missing from the experience of vaping?
PS I like your avitar;)

The whole vaping experience is awesome, so it's not that. I enjoy my e-cig and it sure seems to take care of my nic needs and the physical habit. I never crave a cigarette. That's what's so amazing about this device. Even while I feel like something is lacking, the e-cig is such a good substitute that my brain doesn't make a subconscious connection between *something missing* and *need tobacco*.

It's been very difficult to put my finger on what exactly is missing because it's so nondescript. But I recently went to the doctor for a checkup (first doctor's visit I've had since I quit smoking/started vaping) and explained to him how I really just felt lousy and not like myself. He talked about the MAOIs in tobacco, suggested I was probably self-medicating with cigarettes without knowing it and prescribed an antidepressant.

I haven't filled that prescription yet, but I think I'm going to. I guess then I'll know if it's that MAOI effect that I've been lacking. The more I read about depression, the more I realize that it's exactly what I've experiencing since quitting smoking. It's quite normal to go through that for a few weeks after quitting, of course, but after five months, no.

It's weird to think that something so bad for me might have actually been helping me (I mean helping my brain chemistry). I've been tempted to try snus for a few days to see if that would fix me, but the idea of sticking a little pouch in my mouth isn't very appealing. So as much as I don't like the idea of getting on an antidepressant, it might just be what I need for a few months.

Sorry for the lengthy reply!
 

sanfordf

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Interesting study. I never gave it much thought, but it seems to be a valid argument that SNUS would enhance the absorption of nicotine from vaping. I do SNUS sometimes and while doing so, I don't hit my PV as much, now that I think about it. But I would think that would be from the aggregate accumulation of nicotine and not the enhanced absorption.
 

TWISTED VICTOR

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It's been very difficult to put my finger on what exactly is missing because it's so nondescript. But I recently went to the doctor for a checkup (first doctor's visit I've had since I quit smoking/started vaping) and explained to him how I really just felt lousy and not like myself. He talked about the MAOIs in tobacco, suggested I was probably self-medicating with cigarettes without knowing it and prescribed an antidepressant.

I haven't filled that prescription yet, but I think I'm going to. I guess then I'll know if it's that MAOI effect that I've been lacking. The more I read about depression, the more I realize that it's exactly what I've experiencing since quitting smoking. It's quite normal to go through that for a few weeks after quitting, of course, but after five months, no.

Why not try Swedish snus instead? Many ex-smokers end up spending the rest of their lives using antidepressants when their bodies can't regulate proper dopamine release and re-absorption. Swedish snus is the real thing, and I'd challenge anyone to show proof of any antidepressant on the market that can claim to be even half as safe to use. Unfortunately, it carries the tobacco stigma, so even doctors usually don't bother to consider it. In one days time snus will let you know if your doctors right. It usually takes several days to determine if a prescription antidepressant is doing anything, then regular doctor visits to fiddle with the dosage adjustments. And if it doesn't help, you can't just stop taking it, the dosage will need to decrease over time to ween the body from it. Just my thoughts :).
Interesting study. I never gave it much thought, but it seems to be a valid argument that SNUS would enhance the absorption of nicotine from vaping. I do SNUS sometimes and while doing so, I don't hit my PV as much, now that I think about it. But I would think that would be from the aggregate accumulation of nicotine and not the enhanced absorption.

sanford, snus and eliquid stand seperately, the pH in the snus is what keeps the nic in a free-base form. If the pH in eliquids could be optimized like in snus, more of the nic content in the eliquid should be bio-available. At least that's the theory. The question is if it makes for better vaping if a higher pH drink is consumed at the same time......kind of a nifty angle, huh :).
 
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