Nicotine may cause cancer, says article

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Grinch

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Jun 5, 2010
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Please tell me this is bull..... A friend of mine sent me this article after I told him I was switching to e-cigs.

Since I can't post links yet, this is from TimesOnline.

'Cancer risk of nicotine gum and lozenges higher than thought'

Nicotine chewing gum, lozenges and inhalers designed to help people to give up smoking may have the potential to cause cancer, research has suggested.

Scientists have discovered a link between mouth cancer and exposure to nicotine, which may indicate that using oral nicotine replacement therapies for long periods could contribute to a raised risk of the disease. A study funded by the Medical Research Council, led by Muy-Teck Teh, of Queen Mary, University of London, has found that the effects of a genetic mutation that is common in mouth cancer can be worsened by nicotine in the levels that are typically found in smoking cessation products.

The results raise the prospect that nicotine, the addictive chemical in tobacco, may be more carcinogenic than had previously been appreciated. “Although we acknowledge the importance of encouraging people to quit smoking, our research suggests nicotine found in lozenges and chewing gums may increase the risk of mouth cancer,” Dr Teh said. “Smoking is of course far more dangerous, and people who are using nicotine replacement to give up should continue to use it and consult their GPs if they are concerned. The important message is not to overuse it, and to follow advice on the packet.”

Most nicotine replacement products have labels advising people to cut down after three months of use and to stop completely after six months.

Although nicotine is acknowledged as the addictive element in cigarettes its role in cancer has long been disputed. It is not as potent a carcinogen as other chemicals found in tobacco smoke, such as tar, but some previous research has suggested that it may also contribute to the formation of tumours.

Nonetheless, it is much less dangerous than cigarettes and is therefore used in a wide variety of smoking cessation products that allow addicts to satisfy a craving for the chemical without smoking.

In the new research, published in the journal Public Library of Science One, Dr Teh’s team has investigated the role of a gene called FOXM1 in mouth cancer.

A mutation that raises the activity of this gene is commonly found in many tumours, and is also present in pre-cancerous cells in the mouth, the scientists found. This raised expression can then be worsened by exposure to nicotine, according to Dr Teh.

“If you already have a mouth lesion that is expressing high levels of FOXM1 and you expose it to nicotine, it may add to the risk of converting it into cancer,” he said. “Neither the raised FOXM1 nor nicotine is alone sufficient to trigger cancer, but together they may have an effect.

“The concern is that with smokers, you are looking at people who are already at risk of oral cancer. I’m worried that some may already have lesions they don’t know about in the mouth, and if they keep on taking nicotine replacement when they stop smoking products they will not be doing themselves any good.”

The findings could also lead to new ways of diagnosing mouth cancer while it is still in its early stages and easier to treat.

Dr Teh emphasised that smokers should not stop their attempts to give up. “There is no doubt about the harmful effects of smoking, so smokers should make every effort to quit.”


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Are they just trying to demonize smokers and ex-smokers into feeling bad that they are harming their body? Because I won't doubt nicotine probably isn't great for you, but they could probably do an article of caffeine or something and show all the horrible things THAT does, but you don't see them as often.
 

CaptJay

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Many veggies contain nicotine - does the report mention those too? Are they suggesting we cut down on certain veggies?
I'd call BS on this btw - plenty of previous studies found no link with nicotine and cancer, or such a small risk as to be 'acceptable'. Id say there was more risk from pollutants in the air generally.
Read this article Does nicotine cause cancer?
btw the research on FOX1 was in 2009 its not new and many scientists think its badly done research.
 

DenniZ

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I once had pathophysiology teacher who stated, "If you live long enough, you will most certainly die of cancer. He was simply stating that barring a death from some other illness/condition, your DNA will eventually develop the necessary changes to override the cells instructions to cease replicating.

Through my clinical rotations at several hospitals, and through class, I have both learned and seen first-hand that lung cancer is typically far more lethal then oral cancer. This is for several reasons, two of them being, oral cancer is more likely to be detected early due to its position, and lung cancer is in a critical organ that is far more vascularized. The fact that it sits in such a blood rich environment gives it the potential to grow and metastasize very quickly.

Although this line of reasoning may be rendered moot if indeed nicotine inhalation is found to cause lung cancer, as stated in the article, adding tar and other known carcinogens into the mix, (as with conventional cigarettes), is a less attractive option.
It's just a personal preference but I find suffocation due to COPD slightly scarier then either forms of cancer.

Thanks for posting this thread so that others can look into this and make their own informed decisions.

-Dee
 

Enigma32

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Dec 14, 2009
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'Cancer risk of nicotine gum and lozenges higher than thought' - Times Online

The "journalist" bent the truth significantly. What else is new.

Like Captjay said, this research is nothing new.

Read the story closely. If you *already* have mouth cancer growing, then nicotine *may* have an effect on it. They absolutely, positively, did not imply nicotine causing cancer.

Personally, its kind of a moot point. You already have cancer.
 

kristin

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Aug 16, 2009
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'Cancer risk of nicotine gum and lozenges higher than thought' - Times Online

The "journalist" bent the truth significantly. What else is new.

Like Captjay said, this research is nothing new.

Read the story closely. If you *already* have mouth cancer growing, then nicotine *may* have an effect on it. They absolutely, positively, did not imply nicotine causing cancer.

Personally, its kind of a moot point. You already have cancer.
What Enigma said.

You have to already have pre-existing conditions in place - mouth lesions. Not only do you have to have the pre-cancerous cells already present in your mouth, those cells also have to have triggered a mutation in a specific gene and caused a tumor. ONCE those conditions are met, your CHANCES of worsening the tumor are increased. It specifically says that nicotine alone is NOT SUFFICIENT to trigger mouth cancer.

Interestingly, they don't say what those chance are in a percentage. Is it increased by 10%, 80% or 1%?

Quitting smoking already DECREASES your chances of mouth cancer by nearly 99%. So even if the nicotine DOUBLES your chances of mouth cancer, it's still only approximately a 2% risk, You have a greater chance of getting in a car accident - which has a 2-8% risk of death!
 
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