Nicotine is not associated with cancer or CVD (cardio-vascular disease: heart disease, stroke, etc.).
This means it does not cause it and it does not make an existing condition worse,
on average. This means that for normal people, there is little or no risk. For those with vulnerabilities it is a different matter:
- For example, if you have an existing medical condition related to this area, the above does not apply to you
- If you have a genetic predisposition to certain conditions, such as CVD, the above does not apply to you
So the answer to your question will vary according to who the subject is. People with a family history of early death from heart disease or stroke will need to take care.
With specific regard to blood pressure, note the following:
1. Nicotine is a vasoconstrictor. It will raise the blood pressure acutely (this just means at the time it is consumed, nothing more).
2. Dr Newhouse has a body of evidence showing that nicotine lowers the blood pressure chronically (this just means over time, and nothing more). He states that medium-term nicotine consumption can be shown to reduce the systolic (but not diastolic) pressure. So in point of fact, nicotine lowers 'half' of the blood pressure measured in medium-term consumers of pure nicotine who have never smoked.
Acute means 'at that time'.
Chronic means 'over time'.
Dr P Newhouse
Paul Newhouse of Vanderbilt is currently regarded as the leading expert on practical nicotine issues, because he has the most experience with administration of the pure compound to never-smokers. He has administered large quantities of pure nicotine to non-smokers who included many never-smokers, daily, for months at a time, in multiple clinical trials for the investigation of nicotine's positive effects for certain medical conditions. He almost certainly has the best current database for the effects of pure nicotine on tobacco-naive subjects (those who have never smoked or consumed tobacco in any form). To avoid repetition and needless work here, all the citations for the above statements are listed on my personal website, on the References page, and the Vaping Quotes page:
E-Cigarette Politics
The current state of medical knowledge on nicotine consists of two bodies of work: research on tobacco and smokers that claims to have relevance to nicotine, and research on pure nicotine administered to never-smokers. It seems logical that only materials relevant to the specific compound administered to never-smokers has any value; trying to determine the effects of one item from the immensely long list in consumption of tobacco containing up to 9,600 compounds (Rodgman, Perfetti 2013) does not seem valid.
The conclusions taken from these two bodies of work are radically different. Traditionally, nicotine was only examined in connection with smoking; or rarely, in connection with ST use (smokeless tobacco such as Snus). Any perceived value in such work has been completely destroyed by recent developments, although the propaganda based on it is still widely circulated. Most of this older body of work can be accurately described as complete rubbish.
Nicotine is now regarded as relatively harmless (assuming the subject consuming it is average); and far less toxic than previously claimed. Finally, of course, there is no person known to medical science who has ever become dependent on nicotine without exposure to tobacco, and it is looking increasingly likely that this is either impossible or as close to it as makes no difference. The potential for pure nicotine to create dependence is about zero.