I'm on wellbutrin, so nicotine seems to do /nothing/. I don't get sick from it as long as I take my wellbutrin but I don't get a rush from it either. However at least part of my addiction is the action of smoking, especially if I'm drinking, so I used vaping to replace that and it's nearly as effective in calming as if I wasn't on wellbutrin. It's why I get 0 mg liquid. 