I have occasionally woke up during the night, typically to use the bathroom (not often!) and thought "what the heck" and took a few hits. I usually regret it because the nicotine keeps me awake for hours. I also "try" not to vape once I get in bed at night or the same thing happens... I usually go to bed around midnight, but if I vape in bed, I can be awake until 3-4 am. Not a good idea. A few times after I started vaping (pretty much nonsmoker) I woke up during the night trying to vape my pillow lol. Some people can get up during the night and vape/smoke, but not I. I have really grown to enjoy the first vape of the day, usually still in bed, because I usually get a nice buzz (even with low nicotine), and it helps me wake up. I've always been super sensitive to caffeine, so I tend to avoid it (if I drink anything with caffeine after about 1pm, I can expect to be awake until 3-5 am) but nicotine doesn't have as drastic an effect.. I can vape right up *until* I go to bed and sleep like a baby, but it helps me stay awake and concentrate during the day.