On the road to Crack Nicotine?

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TropicalBob

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Jan 13, 2008
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This is a long and fascinating article I found while trying to discover a way to extract nicotine from tobacco leaves (not really going to do it, but interested in how it's done). Joe, you'll love this one. I'm posting rather than giving another site our hits.

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Irresponsibility Run Amok

President Bush often eloquently argues for "a new ethic of responsibility” in America, in which Americans assume more personal responsibility for their individual choices and the consequences of their actions. He should consider, then, Betty Bullock, and the members of the California jury that awarded her $28 billion last week, as the antithesis of responsible morality.

Betty started smoking when she was 17. Warned constantly by her doctors for 40 years to stop smoking, she would belligerently respond: "I’m an adult. This is my business.”

Now 64, she ceased being an adult responsible for her life decisions once she got lung cancer, and sued Phillip Morris, makers of the Benson & Hedges cigarettes she smoked all those years, for fraud instead.

In a debauch of irresponsibility, Betty’s jury members pathologically indulged her demand she be treated as a child rather than an adult. Approving law professors at Stanford University said that such giant anti-tobacco punitive awards means a growing number of Californians "have strong doubts about whether cigarettes should remain for sale.”

Little do they realize the nightmarish possibilities of their doubts.

The Right to Be Stupid

In a free country, one ought to have the right to be smart, and the right to be stupid – as stupid as you want to be, provided you initiate no violence to others.

Smoking tobacco is unfathomably stupid. Betty Bullock – or anyone who smokes - is an idiot. Cigarette smoking accounts for some 400,000 cardiopulmonary deaths a year in America, more than 60 times the number of deaths (6,000 to 7,000) attributed to all illegal drugs combined.

Tobacco use is one of the greatest health hazards in America today, needlessly causing hundreds of billions of dollars annually in medical expenses. If Californians desired a truly effective disincentive regarding nicotine use, they would pass a referendum excluding anyone suffering a nicotine-caused disease - and thus a voluntarily acquired disease - from any government medical benefits.

Drug users should not be treated as helpless victims. A tobacco addict is no more justified suing a cigarette manufacturer than a ....... addict would be suing her supplier. She cannot expect the taxpayers to pay her medical bills resultant from the willful self-destruction of her health, or for her drug pusher to financially reward her for her drug habit.

Orgies of Greed

But the last thing on earth a liberal lawyer or politician wants is to have the law treat people as responsible adults. A lawyer’s bread-and-butter is infantilizing their clients into helpless children. A politician would much rather use the problems caused by tobacco addiction as a rationale to raise taxes.

In tandem with anti-tobacco juries engaging in orgies of indulgence, anti-tobacco politicians in state after state around the country are engaging in orgies of greed. Tobacco taxes have become a golden goose for government coffers. With a city tax alone of $1.50, a pack of cigarettes now costs $7.50 in New York City.

The tobacco companies’ standard objection is that higher taxes will lead to more cigarette smuggling. The anti-tobacco crowd’s standard response is to demand adjacent cities and states have ever-higher tobacco taxes as well.

Yet the entire argument regarding increased taxes and cigarette smuggling is irrelevant and astoundingly naïve. The true threat is unimaginably worse.

Nicotine as an Insecticide

Nicotine is a naturally occurring substance found in many plants, such as eggplant. Its highest concentration occurs in tobacco leaves. Its function is to protect the plant against insects, i.e., it is a natural insecticide.

Black Leaf 40, an environmentally safe and biodegradable agricultural insecticide used around the world, is 40 percent nicotine sulfate. Farmers have been using nicotine sulfate insecticide since the early 1800s. To make it, all you do is boil tobacco leaves in water with a little sulfuric acid (the same acid as in a car battery).

Free-Basing Nicotine

If you mix the resultant nicotine sulfate extract with a common alkali such as lime, then add a solvent such as ether, pure nicotine alkaloid - or free-base "crack” nicotine - will float to the top dissolved in the solvent, which is then evaporated off. A trivially simple procedure that anyone with a high school chemistry course can perform, it is the same process as making free-base ....... from ....... hydrochloride powder.

And just as "crack" or free-base ....... is far more addictive and lethal than ....... hydrochloride powder, so crack or free-base nicotine would be frighteningly more addictive, and lethal, than tobacco.

The faster a drug rises in the brain, and the higher its concentration, the more potentially addictive it is. Smoking tobacco leaves is a quick and concentrated, and thus addictive, way to administer nicotine - unlike the nicotine skin patch, which delivers the drug slowly. Faster still, much faster and far more concentrated, than smoking plant leaves would be smoking nicotine free base.

Tobacco companies have been aware of this for years. In 1973, R.J. Reynolds Tobacco determined that certain of their competitors (such as Phillip Morris’ Marlboro) were dosing their tobacco with ammonia. This makes the smoke more alkaline, enabling more of the nicotine to be in the smoke, giving it a higher "kick.”

For the same reason, chewers of coca leaf in the Andes always do so with a little lime. New Guinea tribespeople carry a gourd full of powdered lime with a thin bone of the cassowary bird as a stopper; when they chew betel nut, they lick the lime off the bone.

It is thus a small leap to apply these primitive practices and crack ....... chemistry to tobacco, and make full strength, pure free-base nicotine.

Nicotine as an Addictive Poison

Nicotine is the most addictive substance known to science. It is far more addictive than any illegal drug, including ...... (that is, a lower percentage of nicotine addicts are able to permanently quit than ...... addicts). Smoking crack nicotine would be the fastest way to administer the drug, making crack nicotine many times more addictive than tobacco.

Nicotine acts by stimulating the nicotinic cholinergic receptors located throughout the brain and body. If these receptors are mildly stimulated, such as via smoking tobacco leaves, there will be a sensation of heightened alertness, an improved capacity to focus and block out extraneous stimuli.

Just as the high of crack ....... is experienced more intensely by the addict than snorting coke powder, so will the high of crack nicotine be more intensely pleasurable to the tobacco addict than smoking tobacco leaves. But if the nicotinic cholinergic receptors are stimulated too strongly, one's brain and body will go into fatal convulsions.

In its ability to quickly and massively overstimulate one's nicotinic cholinergic receptors, crack nicotine is incredibly poisonous. One drop of 40 milligrams of pure uncut crack nicotine smoked in a glass pipe has a 50 percent chance of killing an adult. Two drops will kill you for sure. It is more toxic than cyanide, one-tenth (gram per gram) as toxic as typical military nerve gas. A few drops on your skin, one or two drops on your mucous membranes, and you are dead.

Poisonous Enough to Kill Castro

Thus purveyors of crack nicotine would have to cut or dilute it with water (as it’s water-soluble) by about 20-1. The nicotine sulfate in Black Leaf 40, on the other hand, cannot be absorbed by the skin or membranes well; it is poison only if you swallow it – like an insect is supposed to.

The famous "poison pen” with which the CIA, per John Kennedy’s request in 1963, tried to kill Fidel Castro was a hypodermic needle disguised as a ballpoint pen and filled with Black Leaf 40.

Do the Math

There is an average of 2 milligrams of nicotine in one high-nicotine cigarette. Total state and city taxes in New York City are now about $3 for a pack of 20: a tax of 7.5 cents per milligram, or $75,000 per kilo of nicotine in cigarettes.

Three drums of nicotine sulfate extract would yield one drum, or 200 kilos, of crack nicotine. This could be manufactured at an average cost (ingredients, equipment, Third World labor) of less than $500. The tax avoidance value (@ $75,000 a kilo) is 30,000 times that: 15 million dollars for one drum of crack nicotine. That is a 3 million percent profit.

Further, one eyedropper-full of uncut crack nicotine would have a nicotine content of four cartons of cigarettes, one kilo poured in a 20-ounce soda-pop bottle would equal 5,000 cartons or 50,000 packs: a value-per-volume increase of 1,000 times for cigarette smugglers. A typical fix of cut crack nicotine (diluted 20-to-1, or 2 mg) would be 1 percent of a crack ....... fix (200 mg) by weight: making it 100 times easier, in terms of size, to smuggle than ........

Enter the Mob

Given these numbers, the politicians’ greedy tobacco tax crusade makes the creation of a crack nicotine market inevitable and irresistible to organized crime. And soon.

More Americans are addicted to nicotine than any other drug. The market for crack nicotine is in the tens of millions of addicts, vastly exceeding any illegal drug by orders of magnitude. Crack nicotine would be far more lucrative for drug dealers and organized crime than ......, ....... or anything else.

The mortality rate from overdosing, compared to that of any other drug, would be of equal dimensions. Because crack nicotine would have a market 100 times larger, and a profit margin 100 times greater than crack ......., such plagues as drive-by shootings, gang turf wars, violent crimes by addicts needing fix money, and the corruption of judges and entire police forces could explode exponentially.

Fantasies and Consequences

The fantasy of anti-tobacco activists, that ever-higher jury awards will stop cigarette sales or ever-higher tobacco taxes will result in fewer people smoking, is going to result in a hideous nightmare instead.

The anti-tobacco activists must realize there are far better alternatives to jury-award and tax crusades. They could become advocates of adult responsibility, and demand that taxpayers not subsidize the medical consequences of tobacco addiction. They could demand safe alternatives to cigarettes, such as Nico Water (mineral water laced with 2 mg of nicotine), recently banned by the FDA and ignorantly opposed by anti-tobacco groups such as Tobacco Free Kids.

Unless they abandon their fantasies and adopt realistic alternatives, such groups are about to learn a horrible lesson taught by the Law of Unintended Consequences – and all of us will suffer for it.
 

Oliver

ECF Founder, formerly SmokeyJoe
Admin
Verified Member
Wow, great read Bob!

So I guess the unlicensed e-cigarette could take the place of the crack-nicotine mobs in this story?!

I have wondered for a while what form the nicotine in the e-cig is, whether it is particulate or freebase. Do you have any ideas?

Thanks for posting.

SJ
 

keys

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That writer sounds like he's the one on drugs. If you are going to skip health care for people who smoke, how about people who are obese and have heart conditions, hypertension, etc. How about people who drink alcohol and are subject to every disease known to man and not to mention car accidents. How about risky sports? Liberal lawyers don't want responsible adults? Give me a break. What a freaking ...... Politicians do sin taxes because people don't complain and that's where they see easy money. Whatever Betty's award was the numbers in these kinds of cases are simple silliness that the press likes to report on, like that guy who spilled hot fast food coffee on himself. A shyster lawyer rolls a company with pockets, it gets publicity, but what the press doesn't report is that on appeal it always gets reduced to few K$. Not that this makes the lawsuit any less stupid but the excesses of the legal profession and society's need for personal responsibility are two different issues. Although the FDA should back off all nic products not associated with tobacco and sell them all OTC.
 

nqhqhz

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Jan 1, 2009
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Crack nicotine is a funny idea but the author should try it out before thinking it would become a drug epidemic. People only take drugs when they are fun - smoking freebase nicotine wouldn't be fun, depending on dose it would either have the same effect as e-cigarettes with none of the habit replacement, or immediate nausea, headaches and other symptoms of nicotine OD. Tobacco tea, anyone?

With pleasurable drugs, people are always seeking more concentrated forms and more direct routes of administration. How many cigarette smokers have moved on to N. Rustica, the cousin of cigarette tobacco, with its much higher nicotine concentration? With the tolerance associated with ......, users can quickly move from smoking to IV injection; this doesn't happen with nicotine, because nicotine doesn't work like ....... I like to smoke a hookah, which definitely delivers more of a buzz than any sort of cigarette, but I am happy to go back to regular or electronic cigarettes when there is no shisha.

It's funny that in an anti-prohibition article the author makes the same mistake that yelling-granny prohibitionists do; conflates the effect of different substances.

Banning tobacco (or for that matter e-cigarettes or any other substance) while there are still smokers wouldn't result in this, just more smuggling, more people criminalised for their own choices, and the erosion of more civil liberties.
 

Kate

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Jun 26, 2008
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This might be of interest on this thread:

"A third thing that ammonia-like compounds can do is increase the pH, increase the amount of free base nicotine, or what Dr Rickert earlier referred to as unprotonated nicotine.... The free-based form of ....... or the free based form of nicotine is more rapidly absorbed, has a more explosive effect on the nervous system. Ammonia is one of the ways that you can provide free-based ....... or free-based nicotine."

YESMOKE: cigarettes Yesmoke - Stub Out The Chemicals - Enhancing Impact

Our vapour has been tested as alkaline by Dr Loi, maybe we already are freebasing nicotine and that's why we hear of so many overdose sufferers.
 

nqhqhz

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Jan 1, 2009
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This might be of interest on this thread:

"A third thing that ammonia-like compounds can do is increase the pH, increase the amount of free base nicotine, or what Dr Rickert earlier referred to as unprotonated nicotine.... The free-based form of ....... or the free based form of nicotine is more rapidly absorbed, has a more explosive effect on the nervous system. Ammonia is one of the ways that you can provide free-based ....... or free-based nicotine."

Our vapour has been tested as alkaline by Dr Loi, maybe we already are freebasing nicotine and that's why we hear of so many overdose sufferers.

My understanding used to be that cigarette smoke is alkaline, but according to the article Some aspects of the chemistry of cigarette smoke which you could look up as I can't link to it, it is acidic. Alkaline environments support nicotine absorbtion better (hence why you can enjoy cigar smoke without inhaling) as well as increasing freebase nicotine.

The Ruyan study does not mention if the nicotine in the vapour is a salt which would tend to favour that it is a base form (I can't confirm this).

However, my personal belief Kate is that we are seeing more overdoses because the self-regulation inherent in burning tobacco is not present in e-cigarettes, and even if you have too much liquid in an inhaler you will still instinctually inhale and draw the same amount of vapour. I believe the same would be true if we had nicotine sulfate in e-liquid.
 

Satire

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Nov 5, 2008
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Give an idiot a little factual information and he can turn it into a big steaming pile of bull****... wow
Freebase ....... is just ......., it isn't some super-powerful version of the drug. The only reason users get a faster and stronger high is because it is smoked (the reason for using the free-base form is because it has a lower boiling point and can be vaporized, ....... HCl is a salt form of the drug and thus has a much higher vaporizing temp, and will usually burn and decompose before reaching vapor temp). If you were to use a carrier vapor (like PG or VG) to deliver ....... HCl to your lungs, it would be just as powerful as the freebase. The term "crack" is a slang term for the crude freebase that the ......s whip up with baking soda, calling anything else the "crack" version of a chemical is just a transparent technique to associate it with something that people have a negative opinion of. In theory, converting the nicotine in tobacco into the freebase form before use would increase the QUANTITY (not quality!) of the nicotine molecules that make it to the lungs because more would be vaporized before reaching the deterioration point. However, in the aerosol liquid that we use, the nicotine isn't vaporized in the conventional way, the PG is turned into gas by the low heat and suction applied (chemicals vaporize at lower temperatures in a vaccum), and the nicotine is carried with it in the vapor, and never gets close to its boiling point (theorizing, I'm not sure how hot it really is in there, but the physics of the carrier vapor is correct). Therefore, making freebase nicotine eliquid would be no more potent than the salt form of nicotine except that the weight of the freebase nic is slightly less per molecule so dose would be SLIGHTLY lower, but once it is in there, the only thing that matters is the number of nicotine molecules, not the form. The reason "crack" is more potent than ....... hcl is because of the method of ingestion (ours would be the same method of ingestion and thus have no greater potency), if one swallowed a pill of freebase ....... or swallowed an equimolar amount of ....... hcl, they would have the EXACT same effect on the body.

Homeboy who wrote that article should receive a nice ..... slap IMHO, he started with total BS logic and then went on a paranoid pipe dream rant about how soon we will have street wars and mob activity for the distribution of his mythological "crack" nicotine... urg. And he just took 20 min of my research time :p I think the scientist who first made anthrax did so after having a prophetic vision of this jackass's article being published and thought it would be a good idea to prepare. RAWR AT HIM
 
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