PC or VG - a question for scientific savvy people pls?

[nomoresmoxe]

I am slowly withdrawing from tranquilisers and I have to be very careful what I imbibe.

I can not imbibe anything which acts on the GABA receptors, as this will disrupt my healing.

I tried to google but came up with loads of scientific bumph which I couldnt make any sense of.

Does anyone know if PG or VG act on the GABA receptors like alcohol.

Many thanks

 

[CaptJay]

I dont think either PG or VG acts on anything in that way - its a sort of sugary watery mix

"Propylene glycol is rapidly absorbed after oral administration
and appears in the blood-stream. After a dose of 8 ml/kg bw had been
administered to dogs approximately 24 hours were required for complete
elimination from the blood-stream (Hanzlik et al., 1939a). Propanediol
phosphate occurs in brain and liver (Rudney, 1954a) and may be
metabolized by dephosphorylation followed by oxidation Huff & Rudney,
1959).

Propanediol and propanediol phosphate are intermediates in the
catabolism of acetone to acetate and formate: propanediol added to a
liver slice preparation is converted to lactic acid (Rodney, 1954b).
Liver alcohol dehydrogenase oxides the glycol to lactaldehyde (Huff,
1961). Propylene glycol is glycogenic in the fasted rat (Opitz, 1958).
Definite increases in liver glycogen occurred after giving 1 ml/kg bw,
but 0.5 ml produced no change (Hanzlik et al., 1939b). Dogs given
propylene glycol excreted 25 to 50% unchanged in the urine (Hanzlik et
al., 1939a; Lehman & Newman, 1937). In experiments on three human
subjects, 20 to 25% of the dose (1 ml/kg bw) was excreted in the urine
within 10 hours (Hanzlik et al., 1939a). The propylene glycol content
of the saliva was about three times as high as that in the blood.

In the body, propylene glycol stearate esters undergo enzymatic
hydrolysis and absorption in a similar manner to stearate glycerides
(Long et al., 1958)."

Nicotine can affect the brain though:
"Nicotine imitates the action of a natural neurotransmitter called acetylcholine and binds to a particular type of acetylcholine receptor, known as the nicotinic receptor.

Whether it is acetylcholine or nicotine that binds to this receptor, it responds in the same way: it changes its conformation, which causes its associated ion channel to open for a few milliseconds. This channel then allows sodium ions to enter the neuron, depolarizing the membrane and exciting the cell. Then the channel closes again, and the nicotinic receptor becomes temporarily unresponsive to any neurotransmitters. It is this state of desensitization that is artificially prolonged by continual exposure to nicotine. "
(The article - from McGill- is longer but you get the idea)

Looks like you should be ok - I'd check with your specialist/doctor if in any doubt.

 

[nomoresmoxe]

Thank you

 

[Col. Gaunt]

I hear that VG is the safest in terms of people having the fewest amount of possible reactions.

 

[notime4nooky]

excellent explaination. GABA receptors are fairly difficult to activate, especially with a stimulant substance, such as nicotine. the primary neural chemicals affected other than those described so beautifully above, are serotonin( the pleasure hormone) and endoginous opiods ( the brain's natural morphine).