Quitting Smoking Improves Memory - is it the nic?

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juicejunky

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First thing comes to my mind is how long were the smokers deprived of a cigarette before being tested, I'll bet it was long enough they were jonesing real bad.

After about the 8th tour stop with a task, the smokers were probably looking for a place to hide and light up rather than completing the silly test. Small sample, stupid study, but not totally unfeasible that taking hits of carbon monoxide might cause some brain damage.
 

kinabaloo

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As an aside, one thing that definetly works for me in improving recall is Ginko Biloba. After a couple of weeks or so it is quite nocticeable. It is believed that it works by increasing blood flow through through the finest capilaries, and so has othe benefits too stemming from this. Also useful are B-group vitamins and omega-3 oil sources.
 

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poolslime

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There was an article I found where they imaged the brains of subjects with nicotine doses and while giving them tasks to perform (here).

What caught my eye was the following sentence:

Study findings also suggest that nicotine helps focus attention on task demands by shifting cognitive resources from less "used" parts of the brain to regions required for task performance.

This solidifies for me (granted not scientific), that the effect of improved memory/cognitive function is only temporary. It has also been shown that nicotine use can prevent new brain cells from forming, particularly in the hippocampus part of the brain that is responsible for long term memory. If nicotine is in fact causing the brain to adjust and shift cognitive functions to other parts of the brain that aren't as damaged or function better, this would explain the seeming improvement to these functions.

Now, I'm responding, because I have first hand experience to how nicotine/smoking, at least for me, did affect memory and cognitive ability.

What is also known about nicotine is that it acts on the brain by attaching to neuro receptors in the brain. This causes a blocking of nerotransmitters from attaching to receptors which in turn causes such things as increased levels of dopamine (what makes you feel good). These neurotransmitters are how the brain communicates messages throughout the body. What if part of this is to communicate new cell growth? I haven't found any articles to relate to this specifically, but I believe there is still so much that is unknown on the long term effects of nicotine.

With all of that said, I started seeing a holistic practitioner over a year ago, and there were several natural supplements that she gave me due to my smoking. These included amino acids that helped to maintain the physical space in synapses that neurotransmitters traverse, and others to help in the maintenance of dopamine and GABA. All I know is that I didn't think I had any kind of problems, but after 2 months of taking these supplements, I realized I had "brain fog" (had diffculty focusing), because it started to lift. I realized, by way of co-workers who had to remind me of things on occasion, that some information I would get during the day would not make it to long term memory. But I also think it had more to do with my lack of ability to focus.

Now all I can say is, I'm still on these supplements and my brain/head feels normal. I don't have problems focusing anymore, and as far as I can tell no real issues with memory (though how would I know if I did :). During this entire time I had still been smoking analogs, at least until almost 2 weeks ago when I switched to vaping.

I don't have any scientific studies to back this up, it's just my own personal experience and beliefs through this period of my life and study.
 

poolslime

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I know she uses a lot of stuff from Apex Energetics, but one of them have her own label put on by her supplier. The main three I am taking are below with links that I could find about them.

NeuroFlam - link
Gabatone - link

The third is a Dopamine Complex, but I don't know from what company it comes from. I would assume Apex Energetics, but I don't know what product it would link to. The ingredients listed are:

Vitamin B6 - 5mg
(as Pyridoxal-5-Phosphate)​
N-Acetyl-L-Tyrosine - 750mg
Macuna (Macuna pruriens) - 425mg
[standardized to contain 60% L-dopa
(3, 4 Dihydroxy-L-Phenylalanine)]​
Green Tea (Camellia sinensis) (leaves) - 100mg
[standardized to contain 60% EGCG]​
Quercetin - 100mg

Other ingredients: Microcrystalline cellulose, vegetable stearate.

No idea what the majority of that stuff is :p
 

Katya

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As an aside, one thing that definetly works for me in improving recall is Ginko Biloba. After a couple of weeks or so it is quite nocticeable. It is believed that it works by increasing blood flow through through the finest capilaries, and so has othe benefits too stemming from this. Also useful are B-group vitamins and omega-3 oil sources.

You're lucky.



I can testify to the fact that quitting nicotine does NOT improve memory. But don't take my word for it...

nicotine improve memory - PubMed - NCBI

Cigarette abstinence impairs memory... [Exp Clin Psychopharmacol. 2008] - PubMed - NCBI

Also, consider these drugs under development that target nicotinic brain receptors: Targacept: Biopharmaceutical Company - Product Pipeline

Yup!
 

Vocalek

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This just in:

Addict Biol - Froeliger

Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing

Addict Biol. 2011 Nov 15. doi: 10.1111/j.1369-1600.2011.00410.x. [Epub ahead of print]

Froeliger B, Modlin LA, Kozink RV, Wang L, McClernon FJ.
Abstract
Smoking abstinence disrupts affective and cognitive processes. In this study, functional magnetic resonance imaging (fMRI) was used to investigate the effects of smoking abstinence on emotional information processing. Smokers (n = 17) and non-smokers (n = 18) underwent fMRI while performing an emotional distractor oddball task in which rare targets were presented following negative and neutral task-irrelevant distractors. Smokers completed two sessions: once following 24-hour abstinence and once while satiated. The abstinent versus satiated states were compared by evaluating responses to distractor images and to targets following each distractor valence within frontal executive and limbic brain regions. Regression analyses were done to investigate whether self-reported negative affect influences brain response to images and targets. Exploratory regression analyses examined relations between baseline depressive symptoms and smoking state on brain function. Smoking state affected response to target detection in the right inferior frontal gyrus (IFG). During satiety, activation was greater in response to targets following negative versus neutral distractors; following abstinence, the reverse was observed. Withdrawal-related negative affect was associated with right insula activation to negative images. Finally, depression symptoms were associated with abstinence-induced hypoactive response to negative emotional distractors and task-relevant targets following negative distractors in frontal brain regions. Neural processes related to novelty detection/attention in the right IFG may be disrupted by smoking abstinence and negative stimuli. Reactivity to emotional stimuli and the interfering effects on cognition are moderated by the magnitude of smoking state-dependent negative affect and baseline depressive symptoms.
http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2011....
 

poolslime

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The URL got cut off towards the end, so I did a search on that site am providing the missing bit...

Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing - Froeliger - 2011 - Addiction Biology - Wiley Online Library

I was hoping to be able to read the full article, but unfortunately you have to pay for it.

Based on the abstract alone, I have a hard time understanding what they are trying to prove. Performing a test where a subject has been deprived of nicotine for 24 hours puts them in the peak of short-term withdrawal. Depending on how long they have smoked, or have had nicotine intake, will certainly affect their craving, and thus affect their ability to focus on anything other than that next fix. I have also found several comments on different studies that with overnight/short term abstinence of nicotine, one can not distinguish differences between withdrawal symptoms and reduction in performance.

Though, the abstract may not paint the whole picture. Wish I could read the whole article.
 
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