Yeah, to me that much of a resistance jump (if you are using Kanthal, which I would think you would be with the drop in coils) doesn't sound right to me. I'd take the tank apart, check the seals, the posts, try it on another mod (if you have one) to see if it's the tank or the mod causing issues. Slight resistance changes can be normal, those don't sound normal. It could also be an electrical fault in the mod, although I'm not sure.
I might try taking it to a knowledgeable vape shop if you have one near you. They can help you isolate if it's the tank or the mod. If it continues to behave that way, I might consider warrantying the setup, if it's in warranty. I would be concerned. Normally I would think a loose post trap or something, but if it's happening with the drop in coils too, not so much.
Best of luck figuring it out, and I hope you find a solution.
Anna