From Wikipedia:Lobeline: ...and acts as a mixed agonist-antagonist at nicotinic acetylcholine receptors
Mixed agonist-antagonist means partial agonist. Partial agonists bind to a receptor while stimulating it weakly. If a true agonist (natural neurotransmitter, agonist drug) tries to bind to that receptor it is prevented from doing so. Thus (theoretically) it would partially fulfill the craving of the blocked drug, while preventing that drug from having any effect.
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This is a brilliant tricksy move by Ruyan, to circumvent the coming FDA vapeocalypse. I'd bet my bottom dollar that there are established studies about the safety and effectiveness of Lobeline.
They can make money selling their vaporizers (and replacement attys) and the FDA won't be able to touch them. While the rest of us smuggle nic juice through the mail.
Mixed agonist-antagonist means partial agonist. Partial agonists bind to a receptor while stimulating it weakly. If a true agonist (natural neurotransmitter, agonist drug) tries to bind to that receptor it is prevented from doing so. Thus (theoretically) it would partially fulfill the craving of the blocked drug, while preventing that drug from having any effect.
---
This is a brilliant tricksy move by Ruyan, to circumvent the coming FDA vapeocalypse. I'd bet my bottom dollar that there are established studies about the safety and effectiveness of Lobeline.
They can make money selling their vaporizers (and replacement attys) and the FDA won't be able to touch them. While the rest of us smuggle nic juice through the mail.