The biggest thing to pay attention to on a series mosfet box concerning your batteries will be your amps. For example, purple efests 18650 2500 mah batteries are rated at a continuous 20 amps. So that means on a single 18650 you can safely build down to .2-.21ohms before you exceed the rated capabilities of the battery. Now, on a series box running 2 18650's in series the amps theoretically double. Taking into account battery sag its "safe" to assume you will be capable of 35 amps on your box. After doing the math you find that the batteries can safely handle a build down to .25 ohms before exceeding the amp limit.
All that being said, I can't build below .3 on mine before the vape becomes to hot. It also burns the
juice out of your wick so fast that you'll be sucking cotton pretty quickly. I've had my wicking catch fire more than once building lower than .3 which is why I don't go past that floor. Well, that and I've learned the hard way not to push the limits anymore lol. 0.4 ohms has become my "sweet spot" on my series box.
Some helpful tools for you to figure out your what your batteries are pushing are steam-engine.org and the micro coil app. They both have good calculators that will help you figure out how hard your running your batteries.
Hope this helps.