I've been working with an IPV2 for a while now, and it took me a little while to get out of the whole "less is more" mentality - the idea that less ohms will give you more power. Most high-wattage guys are used to their mechs, and when using a mech, that's true. Can't adjust voltage on those, you're stuck right around 4 volts.
Can you build low ohms on a high-power regulated mod and get good results? Sure. You can, but I don't see any reason to. Larger coils with more surface area = more vapor. That's the whole reason behind thick gauge wire with parallel coils / quad coils / twisted wire / etc - still get plenty of surface area with lower resistance that'll work well at lower voltage.
The problem I see is this - thicker gauge wire heats up a lot slower than higher gauge, and uses a lot more amps. On a mech, my builds were anywhere from 0.2-0.5 ohms, and slow heat up time always irritated the crap out of me. I don't want to have to vape before I really vape, if that makes any sense. On the IPV2, I don't worry about ohms too much, I worry about what my coils look like. Dual coils with about 12 wraps of 30 gauge are really nice. Sure, the resistance isn't sub-ohm, but who cares? I can pump up the voltage. Coils heat up almost instantly, like flicking a light switch, vapor doesn't feel like I'm sucking air out of an oven, and - here's what's great - I'm pulling about 10 amps. Vapor is thick and tasty. A 1.2 ohm build using 30 gauge kanthal @ 7 volts will give me over 40 watts, but only 5.8 amps (at the atty). The chip has to pull higher amperage from the battery to provide that much, but not that much more. Just slightly above 10 amps.
Lower drain on the batteries, longer battery life, and better battery life (less strain on the batteries = longer service life). So I stay away from sub-ohming on a regulated mod. There's no reason to.