Snails - Response on Threads Part 3

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AttyPops

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I'm sure you know of these already...

Over the past decade, new research has taught us more about how nicotine affects the brain and the body. Some of it is good news -- for example, a lower incidence of Alzheimer's disease in smokers. Research has pointed to a compound called acetylcholine as the reason. Nicotine is structurally similar to acetylcholine, a naturally-occurring compound that serves as a neurotransmitter. Nicotine binds to nerve receptors and makes nerve cells fire more frequently. In one study, a group of Alzheimer's patients were given nicotine patches, while another received a placebo. Those with nicotine patches maintained their cognitive abilities longer and sometimes even recovered lost cognitive function. A follow-up study indicated that nicotine may also boost cognitive abilities in elderly people who aren't suffering from Alzheimer's but who are experiencing the typical mental decline associated with old age.

.The transformation with nicotine happened when the nicotine patch was introduced. Intended to help smokers quit, the nicotine patch also opened up a whole new way of studying the drug. Suddenly scientists had a reliable delivery system -- one without the numerous carcinogens found in cigarettes -- that could be standardized across various studies. A 1982 study revealed that patients with ulcerative colitis had fewer flare-ups when taking nicotine. However, side effects proved nicotine to be a poor long-term treatment.

In 2000, a study performed at Stanford revealed surprising results about nicotine's effects on blood vessels. Contrary to popular opinion, the study showed that nicotine actually boosts the growth of new blood vessels. The discovery may lead to new treatments for diabetes. Many people with severe diabetes experience poor circulation, which can lead to gangrene and ultimately, limb amputation.

HowStuffWorks "How can nicotine be good for me?"

IDK about the accuracy of such a "public info" list as howstuffworks either. I'm sure you can find better ones.

I find the abdominal nervous system interesting and how it relates to nic (the ulcerative colitis thing) and it functions independently from the brain, but with feedback...or something like that that's all way beyond me.

I'm probably way off in left field.............
 
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CES

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So, yep, if it happens it would be my study, and it would be loosely based on a study that i was involved with (but wasn't an author on) that showed that nicotine improved a couple of aspects of vision in non-nicotine users. But it would be specifically geared toward e-cigs. It's an early thought right now, and would probably change quite a bit before it actually occurs.

I've got a small database related to the positive effects of effects of nicotine, and i study nicotine receptors in the retina at work (but usually i study cells rather than whole people). The link between nicotine receptors and Alzheimer's or Parkinsons link is a really important one :)

The trick has always been to try to relate that research to e-cigs.
 

tiburonfirst

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So, yep, if it happens it would be my study, and it would be loosely based on a study that i was involved with (but wasn't an author on) that showed that nicotine improved a couple of aspects of vision in non-nicotine users. But it would be specifically geared toward e-cigs. It's an early thought right now, and would probably change quite a bit before it actually occurs.

I've got a small database related to the positive effects of effects of nicotine, and i study nicotine receptors in the retina at work (but usually i study cells rather than whole people). The link between nicotine receptors and Alzheimer's or Parkinsons link is a really important one :)

The trick has always been to try to relate that research to e-cigs.

if that will get you a grant and extension of your contract then all is good! ;)
 

AttyPops

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There's also notes in that link above, CES, where any form of nicotine use is contraindicated... (not surprisingly. Wet AMD for example.)

However, separating out the nic from all the other stuff is interesting. The results are valuable, + or -.
The comment about AMD increasing in populations where smog is increasing (nic free) is interesting too. Oxidants.

(<<==== Attempting to be a "muse", or at least to amuse... ;) )
 
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CES

optimistic cynic
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So the study i was involved with was here at UAB. I did some reading of the drafts and put my :2c: in. It contained a comparison of nicotine alone vs the reported negative effects of smoking on several visual tests. It wasn't a great paper, but it was ok.


It's kind of a side idea- my focus (other than teaching) is about what happens in the retina during Alzheimer's - not about nicotine as a treatment, but about what might be happening that makes is possible that nicotine could have positive effects. I'll know in October if the grant application gets a score....it's almost impossible to get funding on the first try. It if it gets a a score, i'll get reviews back that will tell me how to improve it to get funding.

(until i get funding, i'll continue to do lots of teaching and hope that's enough)

Anyway, gonna head out from work. Have to run by home depot and then reduce the fur in the house before my brother arrives this evening.

Have a good night y'all. Thanks for the support and the (a)muse(ment) :)
 
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