Hi
@Miken44! Welcome to ECF!
I have a Target Mini, but got it without a tank. A friend of mine has the combo and seems to like it quite well. Can't speak to coil options for the Guardian, but you can run pretty much any tank on the Target. Just beware that with limited battery capacity, you'll want to watch how hard you push, or you'll be recharging often.
All depends on what you want out of your vape. I have Ego ONE tanks, various Kanger Subtanks, Nautiluses and even ProTank2s. I also have a number of RTAs - Serpent Mini being among my favorite. The Target Mini can handle Ni and Ti coils in TC mode. Kanthal, Nichrome, and SS coils in Watts mode.
I got my Target Mini for a "stealth" device. For me, conserving battery life means slightly higher-ohm coils and lower power. I'm not going to chuck clouds with it, but it's a great portable device for me.