The Link Between Anger and Nicotine Use

[Vicks Vap-oh-Yeah]

I found this interesting - especially the part where they took a group of non-smokers and tested them by using nicotine patches.....if our little molecule is such a danger, why are they testing people with it?

The Link Between Anger and Nicotine Use- The Daily Dose - MSN Health & Fitness

How’d the researchers figure this out? Take a group of non-smokers, throw them into a computer game in which they provoke other players with taunting noises, and watch how they get even—with and without nicotine patches. Those with nicotine patches had a reduced tendency to retaliate, even when provoked. This study is the first to connect the brain system most reactive to nicotine and nicotine’s ability to curb anger.

 

[gashin]

The anti-smoking lobby takes any measure to discredit nicotine

I found this interesting - especially the part where they took a group of non-smokers and tested them by using nicotine patches.....if our little molecule is such a danger, why are they testing people with it?

The Link Between Anger and Nicotine Use- The Daily Dose - MSN Health & Fitness

 

[Letzin Hale]

The anti-smoking lobby takes any measure to discredit nicotine

I thought the point was that Nicotine might help curb anger? How would the antis use that to discredit? Sorry if I missed something.

My personal experience is precisely the opposite of the 'test' indications in that I don't feel as stressed or as likely to react angrily since I went zero nic, so maybe it's not the nic for me but the sucking action, which takes us back to the most contented time of our lives...........

​

 

[katink]

LOL Alan

You know... governments should really make e-cigs mandatory for everyone from 16 up - that's a good way to curb the chance of uproar and revolution to start happening now isn't it!

 

[Angela]

My personal experience is precisely the opposite of the 'test' indications in that I don't feel as stressed or as likely to react angrily since I went zero nic,....

Could that be as a result of you no longer getting 'edgy' about when your next nic fix will bei? ie: do you think you are less edgy than when you were using nicotine regularly, or do you think that it is a possibility that you are recalling how you felt whilst you were reducing your nicotine (and therefore in mild withdrawal) with how you feel now you are no longer adicted?

 

[Kate51]

Problem they would have had from my perspective is if they had tried to take away my nicotine. Wanna see a pst Gramma

 

[LaceyUnderall]

I also find it interesting they used the patch. Personally, I was pretty mean on the patch. However, I was also in an emotionally disturbing place because I was eating myself to a new weight each week.

However, good find Vicks... lots more to digest on this one... Behavioral and Brain Functions | Full text | Nicotine-induced brain metabolism associated with anger provocation (link to the study findings)

 

[gashin]

My point was that the study was carried out in order to discredit nicotine.

I thought the point was that Nicotine might help curb anger? How would the antis use that to discredit? Sorry if I missed something.

My personal experience is precisely the opposite of the 'test' indications in that I don't feel as stressed or as likely to react angrily since I went zero nic, so maybe it's not the nic for me but the sucking action, which takes us back to the most contented time of our lives...........

 

[Rexa]

What about the other stuff that's in the patch? It's not all just nicotine.

21 mg/day
Each rectangular 22 cm² system contains nicotine 114 mg and provides 24-hour rate-controlled delivery of 21 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

14 mg/day
Each rectangular 15 cm² system contains nicotine 78 mg and provides 24-hour rate-controlled delivery of 14 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

7 mg/day
Each rectangular 7 cm² system contains nicotine 36 mg and provides 24-hour rate-controlled delivery of 7 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

Maybe it's the stuff that "controls the release of the nicotine".

 

[gashin]

I'm a pharmacy tech - that stuff is just used as a delivery system and yeah for regulating.

What about the other stuff that's in the patch? It's not all just nicotine.

21 mg/day
Each rectangular 22 cm² system contains nicotine 114 mg and provides 24-hour rate-controlled delivery of 21 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

14 mg/day
Each rectangular 15 cm² system contains nicotine 78 mg and provides 24-hour rate-controlled delivery of 14 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

7 mg/day
Each rectangular 7 cm² system contains nicotine 36 mg and provides 24-hour rate-controlled delivery of 7 mg/day to the patient. Nonmedicinal ingredients: ethylene vinyl acetate copolymer, polyisobutylene and high density polyethylene between polyester backings.

Maybe it's the stuff that "controls the release of the nicotine".

 

[LaceyUnderall]

Ok. So, I went on a hunt for nicotine awhile back... raw nicotine. I ran across several companies like this one Alchem International Manufacturer & Exporter of Nicotine USP

After reading how the nicotine was extracted for pharmaceutical grade nicotine, I about sh*t my pants. Pharmaceutical nicotine is some chemically derived stuff! This comes down to the "guilt by association" philosophy that the only reason why nicotine is demonized is because the carrier (tobacco cigarette) is such a demon. Which it truly is. Even the patches are not "organic" nicotine. So the testing done thus far on nicotine is all pharmaceutical grade stuff.

Truly the only way you could do a test on nicotine would be to extract it as naturally as possible without chemical intervention and then add it to a vegetable base and then do testing.

Wow. Our ecigs could become VERY organic in delivery of nicotine. (sure the nicotine might not have such a strong power, but isn't that a concession some would be willing to make?)

 

[Kitabz]

After reading how the nicotine was extracted for pharmaceutical grade nicotine, I about sh*t my pants. Pharmaceutical nicotine is some chemically derived stuff! [...] Even the patches are not "organic" nicotine. So the testing done thus far on nicotine is all pharmaceutical grade stuff.

If we accept that nicotine is a chemical (which it is - C₁₀H₁₄N₂), what difference does it make how it was obtained - assuming the resulting chemical is free of contaminants?

You may prefer "organic" tobacco leaf to be the origin of the nicotine or less industrial processes to be used to get it out of the tobacco leaf, but in the end, it will yield exactly the same chemical surely.

 

[LaceyUnderall]

If we accept that nicotine is a chemical (which it is - C₁₀H₁₄N₂), what difference does it make how it was obtained - assuming the resulting chemical is free of contaminants?

You may prefer "organic" tobacco leaf to be the origin of the nicotine or less industrial processes to be used to get it out of the tobacco leaf, but in the end, it will yield exactly the same chemical surely.

But how can you be truly sure that the testing done on nicotine is truly yielding the results of the nicotine and not another chemical used in the extraction process?

Are my assumptions wrong that nicotine extracted by chemical means could possibly have a residue from one of those chemicals, not making it pure nicotine anymore?

I am not a scientist by any means... so I am truly curious.

 

[Kitabz]

But how can you be truly sure that the testing done on nicotine is truly yielding the results of the nicotine and not another chemical used in the extraction process?

No, this is a valid point (and why I said "assuming the resulting chemical is free of contaminants"). I would presume (and I stress that I don't know) that pharmaceutical grade nicotine is likely to be >99% pure. The question is what is in the residual <1%?

For it to be pharmaceutical grade, I think it unlikely for it to be anything remotely toxic. Coupled with this, since we consume nicotine in such hugely diluted quantities, we'd be taking about less than 1% of less than 0.36% using the maximum 36mg/ml strength generally available. In the case of the NRT nasal spray at 10mg/ml this would mean less than 1% of less than 0.1% - in other words 0.001% of the total volume (that's one in one hundred thousand).

Are my assumptions wrong that nicotine extracted by chemical means could possibly have a residue from one of those chemicals, not making it pure nicotine anymore?
I am not a scientist by any means... so I am truly curious.

I have more faith in well understood chemical reactions taking place under rigorously controlled conditions than I do about extracting nicotine using - how shall I say - less controlled methods where the end product cannot be pure (or even consistent in some cases) and the percent of nicotine it contains cannot be known. I'd be more afraid of consuming nicotine several times stronger than intended than any tiny quantity of chemical that might be left over from the industrial extraction process.

 

[gashin]

There are several ways to test for purity using NMR, and Gas chromatography.... I'm sure the research studies use these methods because most labs have them. In fact, I attended UCI where that study was carried out and there are several of those machines on campus, even open to the undergraduates!

But how can you be truly sure that the testing done on nicotine is truly yielding the results of the nicotine and not another chemical used in the extraction process?

Are my assumptions wrong that nicotine extracted by chemical means could possibly have a residue from one of those chemicals, not making it pure nicotine anymore?

I am not a scientist by any means... so I am truly curious.

 

[LaceyUnderall]

kitabz/gashin -

thanks for the science lesson

all of this comes from wanting to understand a: the downfalls of people being forced to make this stuff in their kitchens... which concerns me greatly and b: finding a better way to extract AND keep consistency in mg's as kitabz touched on...

we were thinking of a fun experiment, basically taking tobacco and putting it into a no-nicotine base and then measuring the nicotine in it every day for x amount of time. brewing it kind of like you would whiskey.

since we consume nicotine in such hugely diluted quantities, we'd be taking about less than 1% of less than 0.36% using the maximum 36mg/ml strength generally available. In the case of the NRT nasal spray at 10mg/ml this would mean less than 1% of less than 0.1% - in other words 0.001% of the total volume (that's one in one hundred thousand).

this was one of the issues with homeopathic. even though it is still a completely viable option, there would be even greater dilution of the nicotine as the HPCUS requires at least 3x I believe to be OTC. for me, a now no-nicotine/low nicotine at parties eSmoker... no big deal... but for others like my hubby who could probably be at 36mg easy... that wouldn't work.

 

[Idahojo]

Well from my personal experience, I don't think it's the nicotine or lack thereof that makes a person edgy or angry. I think it's the other cr@p Big Tobacco puts in it to keep us coming back for more. When I was smoking 2-3 packs a day I would get downright p!ssy when I had to wait for a smoke. Then I got downright aggravated and then some. Now after stopping the analogs I can go for several hours between vaping and not have that experience. Yes I really want to vape but I no longer have homicial thoughts. LOL Just my unscientific conclusion.

 

[LaceyUnderall]

Well from my personal experience, I don't think it's the nicotine or lack thereof that makes a person edgy or angry. I think it's the other cr@p Big Tobacco puts in it to keep us coming back for more. When I was smoking 2-3 packs a day I would get downright p!ssy when I had to wait for a smoke. Then I got downright aggravated and then some. Now after stopping the analogs I can go for several hours between vaping and not have that experience. Yes I really want to vape but I no longer have homicial thoughts. LOL Just my unscientific conclusion.

I agree completely. It's an amazing feeling. You own your smoking now, it doesn't own you.

 

[Kitabz]

kitabz/gashin - thanks for the science lesson

No problem!

we were thinking of a fun experiment, basically taking tobacco and putting it into a no-nicotine base and then measuring the nicotine in it every day for x amount of time. brewing it kind of like you would whiskey.

For doing stuff like this in your own kitchen for your own use, the risk is limited. For commercial quantities, that's a different matter. One mistake and you've got hundreds/thousands of lives in your hands. Scary stuff.

this was one of the issues with homeopathic. even though it is still a completely viable option, there would be even greater dilution of the nicotine as the HPCUS requires at least 3x I believe to be OTC. for me, a now no-nicotine/low nicotine at parties eSmoker... no big deal... but for others like my hubby who could probably be at 36mg easy... that wouldn't work.

Don't even get me started on homeopathy. Going from 36mg to about 1/4000 of the strength isn't really going to do it for most people!

Now after stopping the analogs I can go for several hours between vaping and not have that experience. Yes I really want to vape but I no longer have homicial thoughts. LOL Just my unscientific conclusion.

I agree completely. It's an amazing feeling. You own your smoking now, it doesn't own you.

Yes, I find this too. The [nicotine] addiction is still there but it's much less intense than it used to be with cigarettes. I feel quite liberated now-a-days. It's like I've been let out of jail but I'm still on parole!

 

[LaceyUnderall]

For doing stuff like this in your own kitchen for your own use, the risk is limited. For commercial quantities, that's a different matter. One mistake and you've got hundreds/thousands of lives in your hands. Scary stuff.

I should also clarify here that we were talking as in fun for us to do...not to do in our kitchen and sell to the masses (I know you weren't suggesting we would... but I just feel I need to clarify for all of those reading along)